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Designer adhesion GPCR tells its signaling story
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2020-09-28 , DOI: 10.1038/s41589-020-00673-7
Eugenia V Gurevich 1 , Vsevolod V Gurevich 1
Affiliation  

The ADGRL3 receptor, a member of the adhesion G-protein-coupled receptor family, is implicated in many neurological diseases. Using a novel technique involving controlled proteolysis of the receptor’s extracellular domain, this study demonstrated that ADGRL3 signals via G12/13 G proteins.

中文翻译:

设计师粘附 GPCR 讲述其信号故事

ADGRL3 受体是粘附 G 蛋白偶联受体家族的成员,与许多神经系统疾病有关。这项研究使用一种涉及受体胞外域受控蛋白水解的新技术,证明 ADGRL3 通过 G12/13 G 蛋白发出信号。
更新日期:2020-09-28
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