Enhanced Antifungal Activity of WS2/ZnO Nanohybrid against Candida albicans,ACS Biomaterials Science & Engineering

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Enhanced Antifungal Activity of WS2/ZnO Nanohybrid against Candida albicans
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-09-28 , DOI: 10.1021/acsbiomaterials.0c00786
Vidhi K. Bhatt ₁ , Meswa Patel ₁ , Pratik M. Pataniya ₁ , Bragadish D. Iyer ₁ , C. K. Sumesh ₁ , Dattatray J. Late ₂

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Candida albicans forms persistent infections through the formation of biofilms that confer resistance to existing antifungal drugs. Biofilm targeting is therefore a promising strategy to combat Candida albicans infections. The WS₂/ZnO nanohybrids exhibits considerably improved antibiofilm activity and inhibited the biofilm formation by 91%, which is quite better than that for pristine WS₂, which is only 74%. The physical blend prepared by mixing WS₂ nanosheets and WS₂/ZnO in the ratio of 70:30 showed an antibiofilm activity of 58%, which was intermediate to that observed for pristine materials. The as-synthesized nanohybrid also demonstrates dose-dependent antifungal activity as calculated using the disc diffusion test. WS₂/ZnO nanohybrid shows 1.5 times higher activity compared to pristine WS₂ nanosheets suggesting that the nanohybrid materials are more effective as novel antifungal materials.

中文翻译：

WS ₂ / ZnO纳米杂化物对白色念珠菌的增强抗真菌活性

白色念珠菌通过形成生物膜形成持续感染，赋予对现有抗真菌药物的抗性。因此，生物膜靶向是对抗白色念珠菌感染的有前途的策略。WS ₂ / ZnO纳米杂化物表现出显着改善的抗生物膜活性，并抑制了91％的生物膜形成，这比纯净的WS ₂仅为74％更好。通过混合WS ₂纳米片和WS ₂制备的物理混合物ZnO / ZnO的比例为70:30，其抗生物膜活性为58％，处于原始材料的中间水平。合成的纳米杂化物还显示出使用盘扩散测试计算出的剂量依赖性抗真菌活性。WS ₂ / ZnO纳米杂化物显示的活性是原始WS ₂纳米片的1.5倍，这表明纳米杂化物材料作为新型抗真菌材料更有效。

更新日期：2020-11-09

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