Abstract

The present investigation was aimed to study the anti-diabetic and hypolipidemic potential of Cinnamon cassia (Lauraceae family) bark in streptozotocin (STZ)-induced diabetic rats. The preliminary phytochemical analysis (hexane, petroleum ether, chloroform, ethanol, methanol, and aqueous extracts), GC-MS analysis (ethanol), in vitro (aqueous, ethanol and methanol), in vivo (ethanol) and in silico anti-diabetic activity with hypolipidemic effect of C. cassia bark was analysed. The ethanolic extract of the C. cassia bark has a fine inhibitory activity than the aqueous and methanolic extract. Out of 20 different compounds identified, seven compounds were biologically active, and 9-octadecenoic acid has highly interacted with PPARα/γ in docking studies. The levels of diabetic markers, enzymes, and lipid profiles were altered in STZ-induced rats, but after the treatment of C. cassia, the levels were returned to the normal. The study may prove the ethanolic extract of C. cassia has a powerful anti-diabetic and anti-hyperlipidemic activity.

摘要

本研究旨在研究肉桂（樟科）树皮在链脲佐菌素 (STZ) 诱导的糖尿病大鼠中的抗糖尿病和降血脂潜力。初步植物化学分析（己烷、石油醚、氯仿、乙醇、甲醇和水提取物）、GC-MS 分析（乙醇）、体外（水、乙醇和甲醇）、体内（乙醇）和计算机模拟抗糖尿病分析了肉桂树皮的降血脂活性。肉桂的乙醇提取物树皮比水提取物和甲醇提取物具有良好的抑制活性。在鉴定出的 20 种不同化合物中，有 7 种化合物具有生物活性，并且 9-十八碳烯酸在对接研究中与 PPARα/γ 高度相互作用。STZ 诱导的大鼠的糖尿病标志物、酶和脂质水平发生了改变，但在肉桂处理后，水平恢复正常。该研究可能证明肉桂乙醇提取物具有强大的抗糖尿病和抗高血脂活性。