Abstract

1. We investigated the plasma toxicokinetic behavior of free (parent) and total (parent and conjugated forms) of bisphenol S (BPS) and bisphenol AF (BPAF) in plasma of adult male rats and mice following exposure via feed for 7 days to BPS (338, 1125, and 3375 ppm) or BPAF (338, 1125, and 3750 ppm).

2. In rats, the exposure concentration-normalized maximum concentration [C_max/D (ng/mL)/(ppm)] and area under the concentration time curve [AUC/D (h × ng/mL)/(ppm)] for free was higher for BPS (C_max/D: 0.476–1.02; AUC/D: 3.58–8.26) than for BPAF (C_max/D: 0.017–0.037; AUC/D:0.196–0.436).

3. In mice, the difference in systemic exposure parameters between free BPS (C_max/D: 0.376–0.459; AUC/D: 1.52–2.54) and free BPAF (C_max/D: 0.111–0.165; AUC/D:0.846–1.09) was marginal.

4. Elimination half-lives for free analytes (4.41–10.4 h) were comparable between species and analogues.

5. When systemic exposure to free analyte was compared between species, in rats, BPS exposure was slightly higher but BPAF exposure was much lower than in mice.

6. BPS and BPAF were highly conjugated; total BPS AUC values (rats ≥18-fold, mice ≥17-fold) and BPAF (rats ≥127-fold, mice ≥16-fold) were higher than corresponding free values.

7. Data demonstrated that there are analogue and species differences in the kinetics of BPS and BPAF.

摘要

1. 我们调查了成年雄性大鼠和小鼠血浆中双酚S（BPS）和双酚AF（BPAF）的游离（亲本）和总（亲本和共轭形式）的游离（母体）和总（母体和共轭形式）的血浆毒代动力学行为，通过饲料暴露于BPS 7天（338） ，1125和3375 ppm）或BPAF（338、1125和3750 ppm）。

2. 在大鼠中，免费暴露浓度标准化的最大浓度[C _max / D（ng / mL）/（ppm）]和浓度时间曲线下的面积[AUC / D（h×ng / mL）/（ppm）] BPS（C _max / D：0.476–1.02; AUC / D：3.58–8.26）高于BPAF（C _max / D：0.017–0.037; AUC / D：0.196–0.436）。

3. 在小鼠中，游离BPS（C _max / D：0.376–0.459; AUC / D：1.52–2.54）和游离BPAF（C _max / D：0.111–0.165; AUC / D：0.846–1.09 ）之间的全身暴露参数差异）是微不足道的。

4. 游离态分析物的消除半衰期（4.41-10.4小时）在物种和类似物之间是可比的。

5. 比较不同物种对游离分析物的全身暴露，在大鼠中，BPS暴露稍高，但BPAF暴露远低于小鼠。

6. BPS和BPAF是高度共轭的；BPS AUC总值（大鼠≥18倍，小鼠≥17倍）和BPAF（大鼠≥127倍，小鼠≥16倍）均高于相应的游离值。

7. 数据表明，BPS和BPAF的动力学存在类似物和物种差异。