Abstract

The neutrophil–lymphocyte ratio is a simple and easily used parameter for the assessment of inflammation. We aimed to determine the predictive potential of the neutrophil–lymphocyte ratio regarding episode occurrence in patients with hereditary angioedema. Sixty-six patients with Type 1 hereditary angioedema and 60 healthy controls were included in the study. The laboratory results of the patients in their episode-free periods were similar to those of the healthy controls. The median of neutrophil-lymphocyte ratio was higher during episodes when compared to normal periods (3.5 versus 2.0, p < .001). A significant positive correlation was present between the episode count and the neutrophil-lymphocyte ratio calculated during the episodes (r = 0.557, p < .001). We can conclude that the neutrophil-lymphocyte ratio, which is cheap and easy to calculate, can be used by clinicians as a predictive parameter for prediction of the episode count in patients with hereditary angioedema.

摘要

中性粒细胞-淋巴细胞比率是评估炎症的一个简单且易于使用的参数。我们旨在确定中性粒细胞-淋巴细胞比率对遗传性血管性水肿患者发作发生的预测潜力。该研究包括 66 名 1 型遗传性血管性水肿患者和 60 名健康对照。无发作期患者的实验室结果与健康对照者相似。与正常时期相比，发作期间中性粒细胞-淋巴细胞比率的中位数更高（3.5 对 2.0，p  < .001）。发作计数和发作期间计算的中性粒细胞-淋巴细胞比率之间存在显着的正相关（r  = 0.557，p < .001）。我们可以得出结论，中性粒细胞-淋巴细胞比率便宜且易于计算，临床医生可以将其用作预测遗传性血管性水肿患者发作次数的预测参数。