ABSTRACT Epidemiological studies have suggested that there is an association between dietary acid load (DAL) with complications and outcomes of pregnancy. The current study aimed to explore the impact of DAL on theses parameters through a prospective cohort of Iranian pregnant women. In this prospective cohort study, 812 singleton pregnant women without any medical condition, use of medications, and without following a specific diet were included. Dietary intake of participants was examined using a 117-item semi-quantitative food-frequency questionnaire (FFQ). Net endogenous acid production (NEAP) and potential renal acid load (PRAL) parameters were used to explore potential DAL using the suggested formula. Multinomial logistic regression analysis was used and odds ratio (OR) and 95% corresponding confidence interval (CI) were reported. DAL (NEAP and PRAL) was not associated with pregnancy outcomes including birth weight, birth height and birth head circumference (all P values > .05). NEAP was associated with pre-eclampsia (Model 3: OR = 0.48, 95%CI (0.25, 0.94); Ptrend = 0.05), systolic blood pressure (SBP) (Model 2: OR = 3.99, 95%CI (1.09, 14.53); Ptrend = 0.04), diastolic blood pressure (DBP) (Model 3: OR = 2.45, 95%CI (1.05, 5.72); Ptrend = 0.03), and intra-uterine growth restriction (IUGR) (Model 3: OR = 2.82, 95%CI (1.02, 7.78); Ptrend = 0.01). Moreover, PRAL was related with risk of pre-eclampsia (Model 3: OR = 0.41, 95%CI (0.19, 0.86); Ptrend = 0.003), SBP (Model 2: OR = 6.07, 95%CI (1.23, 29.94); Ptrend = 0.03), DBP (Model 3: OR = 3.62, 95%CI (1.23, 10.65); Ptrend = 0.03), and IUGR (Model 2: OR = 2.63, 95%CI (0.93, 7.44); Ptrend = 0.02). Our study focused on DAL which showed a significant association with pregnancy-related complications including higher SBP, DBP, IUGR, and pre-eclampsia. Further research with larger sample sizes in different populations might be required to evaluate the compatibility of DAL during pregnancy

中文翻译：

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孕早期母亲膳食酸负荷与妊娠相关并发症的关系

摘要 流行病学研究表明，膳食酸负荷 (DAL) 与并发症和妊娠结局之间存在关联。目前的研究旨在通过伊朗孕妇的前瞻性队列探索 DAL 对这些参数的影响。在这项前瞻性队列研究中，纳入了 812 名没有任何健康状况、使用药物且没有遵循特定饮食的单身孕妇。使用 117 项半定量食物频率问卷 (FFQ) 检查参与者的饮食摄入量。使用建议的公式，使用净内源性酸产生 (NEAP) 和潜在的肾酸负荷 (PRAL) 参数来探索潜在的 DAL。使用多项逻辑回归分析并报告比值比 (OR) 和 95% 相应的置信区间 (CI)。DAL（NEAP 和 PRAL）与妊娠结局无关，包括出生体重、出生身高和出生头围（所有 P 值 > .05）。NEAP 与先兆子痫相关（模型 3：OR = 0.48, 95%CI (0.25, 0.94)；Ptrend = 0.05）、收缩压 (SBP)（模型 2：OR = 3.99, 95%CI (1.09, 14.53) )；Ptrend = 0.04)、舒张压 (DBP)（模型 3：OR = 2.45，95%CI (1.05, 5.72)；Ptrend = 0.03）和子宫内生长受限 (IUGR)（模型 3：OR = 2.82, 95% CI (1.02, 7.78)；Ptrend = 0.01)。此外，PRAL 与先兆子痫的风险相关（模型 3：OR = 0.41, 95%CI (0.19, 0.86); Ptrend = 0.003），SBP（模型 2：OR = 6.07, 95%CI (1.23, 29.94)） ；Ptrend = 0.03)、DBP（模型 3：OR = 3.62，95%CI（1.23，10.65）；Ptrend = 0.03）和 IUGR（模型 2：OR = 2.63，95%CI（0.93，7.44）；Ptrend = 0.02）。我们的研究侧重于 DAL，它显示出与妊娠相关并发症的显着关联，包括较高的 SBP、DBP、IUGR 和先兆子痫。可能需要在不同人群中进行更大样本量的进一步研究，以评估妊娠期间 DAL 的相容性