ABSTRACT

The outbreak of coronavirus disease 2019 (COVID-19) has posed a serious threat to public health. There is an urgent need for discovery methods for the prevention and treatment of COVID-19 infection. Understanding immunogenicity together with immune responses are expected to provide further information about this virus. We hope that this narrative review article may create new insights for researchers to take great strides toward designing vaccines and novel therapies in the near future. The functional properties of the immune system in COVID-19 infection is not exactly clarified yet. This is compounded by the many gaps in our understanding of the SARS-CoV-2 immunogenicity properties. Possible immune responses according to current literature are discussed as the first line of defense and acquired immunity. Here, we focus on proposed modern preventive immunotherapy methods in COVID-19 infection.

摘要

2019 年冠状病毒病 (COVID-19) 的爆发对公众健康构成了严重威胁。迫切需要发现预防和治疗 COVID-19 感染的方法。了解免疫原性和免疫反应有望提供有关该病毒的更多信息。我们希望这篇叙述性评论文章可以为研究人员提供新的见解，以便在不久的将来在设计疫苗和新疗法方面取得重大进展。COVID-19 感染中免疫系统的功能特性尚未完全阐明。我们对 SARS-CoV-2 免疫原性特性的理解存在许多空白，这使情况更加复杂。根据当前文献，可能的免疫反应被讨论为第一道防线和获得性免疫。在这里，我们专注于在 COVID-19 感染中提出的现代预防性免疫治疗方法。