The Bestmann-Ohira Reagent and Related Diazo Compounds for the Synthesis of Azaheterocycles.,The Chemical Record

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The Bestmann-Ohira Reagent and Related Diazo Compounds for the Synthesis of Azaheterocycles.
The Chemical Record ( IF 7.0 ) Pub Date : 2020-09-28 , DOI: 10.1002/tcr.202000091
Muhammad Fahad Jamali _{1,

2} , Narendra Kumar Vaishanv ₁ , Kishor Mohanan _{1,

2}

Affiliation

Azaheterocycles are one of the most prevalent classes of compounds present in numerous bioactive compounds, natural products, and agrochemicals, and undoubtedly, new methods to access them are always in high demand. Among the methods available, the 1,3‐dipolar cycloaddition reactions involving diazo compounds are particularly attractive because of their ability to rapidly construct densely functionalized azaheterocycles in a regioselective manner. In this context, the Bestmann‐Ohira reagent has become a well‐known reagent for the 1,3‐dipolar cycloaddition reactions to produce phosphonylated heterocycles, besides its widespread use as a homologating agent for the conversion of aldehydes to alkynes. This account details our efforts toward broadening the synthetic utility of the Bestmann‐Ohira reagent and related compounds for the preparation of azaheterocycles such as pyrazoles, spirooxindoles, triazoles, triazolines, and spiropyrazolines, emphasizing on domino multicomponent reactions employing readily available feedstock reagents.

中文翻译：

用于合成Azaheterocycles的Bestmann-Ohira试剂和相关的重氮化合物。

Azaheterocycles是众多生物活性化合物，天然产物和农用化学品中存在的最普遍的化合物之一，毫无疑问，始终需要新的获取方法。在可用的方法中，涉及重氮化合物的1,3-偶极环加成反应特别有吸引力，因为它们能够以区域选择性的方式快速构建致密的氮杂杂环。在这种情况下，Bestmann-Ohira试剂已广泛用于1,3-偶极环加成反应，以生成膦酰化的杂环，此外它已广泛用作醛转化为炔烃的同系物。

更新日期：2020-11-16

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