A simple model is developed to describe the instantaneous (r_v) and cumulative (R_v) recovery of viruses from water during sample concentration by tangential flow filtration in the regime of constant water recovery, r. A figure of merit, M = r_vr, is proposed as an aggregate performance metric that captures both the efficiency of virus recovery and the speed of sample concentration. We derive an expression for virus concentration in the sample as a function of filtration time with the rate‐normalized virus loss, $\eta =\frac{1-r_v}{r}$, as a parameter. A practically relevant case is considered when the rate of virus loss is proportional to the permeation‐driven mass flux of viruses to the membrane: $\frac{d{m}_{\mathit{ad}}}{\mathit{dt}}\sim Q_p{C}_f\gg Q_p{C}_p$. In this scenario, the instantaneous recovery is constant, the cumulative recovery is decreasing as a power function of time, $R_v={\left(1-\frac{Q_p}{V_0}t\right)}^{\eta }$, η mediates the trade‐off between r and r_v, and M is maximized at $r=r_{\mathit{opt}}=\frac{1}{2\eta }$. The proposed model can guide the design of the sample concentration process and serve as a framework for quantification and interlaboratory comparison of experimental data on virus recovery.

中文翻译：

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通过切向流过滤进行病毒回收：指导样品浓缩过程设计的模型

开发了一个简单的模型来描述在恒定水回收率r的情况下通过切向流过滤在样品浓缩期间从水中的瞬时 ( r _v )和累积 ( R _v ) 病毒回收率。一个品质因数M = r _v r被提议作为一个综合性能指标，它可以捕捉病毒恢复的效率和样本浓缩的速度。我们推导出样品中病毒浓度的表达式，它是过滤时间和速率归一化病毒损失的函数，$\eta =\frac{1-r_v}{r}$, 作为参数。当病毒损失率与渗透驱动的病毒对膜的质量通量成正比时，考虑了一个实际相关的案例：$\frac{d{米}_{\mathit{广告}}}{\mathit{dt}}～{问}_p{C}_F\gg {问}_p{C}_p$. 在这种情况下，瞬时恢复是恒定的，累积恢复作为时间的幂函数递减，$R_v={\left(1-\frac{{问}_p}{{五}_0}吨\right)}^{\eta }$, η调节r和r _v之间的权衡, M在$r=r_{\mathit{选择}}=\frac{1}{2\eta }$. 所提出的模型可以指导样品浓缩过程的设计，并作为量化和实验室间病毒回收实验数据比较的框架。