Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell-derived extracellular vesicles,STEM CELLS

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Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell-derived extracellular vesicles
STEM CELLS ( IF 4.0 ) Pub Date : 2020-10-01 , DOI: 10.1002/stem.3278
Silvia Preciado _{1,

2,

3} , Sandra Muntión _{1,

2,

3} , Fermín Sánchez-Guijo _{1,

2,

3,

4}

Affiliation

The therapeutic effects of mesenchymal stromal cells (MSCs) in graft failure or poor graft function after allogenic hematopoietic stem cell transplantation (HSCT) are currently undergoing clinical evaluation. MSCs exert their functions, at least partially, through the secretion of extracellular vesicles (MSC‐EVs). The available information on the biological potential of MSC‐EVs to improve hematopoietic function, both in in vitro studies and in reported preclinical models, focusing on the possible mechanisms of these effects are summarized in the current review. The potential advantages of EVs over MSCs are also discussed, as well as the limitations and uncertainties in terms of isolation, characterization, mechanism of action in this setting, and industrial scalability that should be addressed for their potential clinical application.

中文翻译：

改善造血移植：间充质基质细胞衍生的细胞外囊泡的潜在作用

间充质基质细胞 (MSC) 在同种异体造血干细胞移植 (HSCT) 后移植失败或移植功能差中的治疗效果目前正在进行临床评估。MSCs 至少部分地通过分泌细胞外囊泡 (MSC-EVs) 发挥其功能。本综述总结了体外研究和报告的临床前模型中关于 MSC-EV 改善造血功能的生物学潜力的可用信息，重点是这些影响的可能机制。还讨论了 EV 相对于 MSC 的潜在优势，以及在隔离、表征、此设置中的作用机制以及工业可扩展性方面的局限性和不确定性，这些方面应针对其潜在的临床应用加以解决。

更新日期：2020-10-01

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