N6‐methyladenosine (m6A) RNA modification in cancer stem cells,STEM CELLS

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N6‐methyladenosine (m6A) RNA modification in cancer stem cells
STEM CELLS ( IF 4.0 ) Pub Date : 2020-09-27 , DOI: 10.1002/stem.3279
Zhonghua Ma ₁ , Jiafu Ji ₁

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Cancer stem cells (CSCs), a unique subset of undifferentiated cells with stem cell‐like properties, have emerged as driving forces in mediating tumor growth, metastasis, and therapeutic resistance. Recent advances have highlighted that N6‐methyladenosine (m6A) RNA modification plays an important role in cancer biology and CSCs. Dynamic m6A decoration has been demonstrated to be involved in CSC generation and maintenance, governing cancer progression and therapeutic resistance. In this review, we provide the first overview of the current knowledge of m6A modification implicated in CSCs and their impact on CSC properties, tumor progression, and responses to treatment. We also highlight the potential of m6A machinery as novel targets for cancer therapeutics. The involvement of m6A modification in CSCs provides a new direction for exploring cancer pathogenesis and inspires the development of effective strategies to fully eliminate both cancer cells and CSCs.

中文翻译：

癌症干细胞中的 N6-甲基腺苷 (m6A) RNA 修饰

癌症干细胞（CSC）是具有干细胞样特性的未分化细胞的独特子集，已成为介导肿瘤生长、转移和治疗耐药的驱动力。最近的进展凸显了 N6-甲基腺苷 (m6A) RNA 修饰在癌症生物学和 CSC 中发挥着重要作用。动态 m6A 修饰已被证明参与 CSC 的生成和维持、控制癌症进展和治疗耐药。在这篇综述中，我们首次概述了与 CSC 相关的 m6A 修饰的当前知识及其对 CSC 特性、肿瘤进展和治疗反应的影响。我们还强调了 m6A 机制作为癌症治疗新靶点的潜力。 m6A 修饰参与 CSC 为探索癌症发病机制提供了新方向，并激发了开发有效策略以完全消除癌细胞和 CSC 的作用。

更新日期：2020-12-02

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