Folates are multifunctional metabolites in plants that are essential for cell division, nucleic acids and amino acid synthesis. During symbiotic nitrogen fixation in legumes, these cofactors are needed for de novo purine biosynthesis, meaning that changes in the folate pools could directly affect the flow of fixed nitrogen to the plant. Its role related to symbiotic nitrogen fixation has not been yet explored, but recent data suggest a relevant role during the first steps. Transcriptomic, metabolomic and proteomic analyses indicate that folates are accumulated in symbiotic plant tissue, as they are involved, not only in de novo purines biosynthesis, but in nitrogen translocation, endoreduplication and phytohormones biosynthesis. Understanding the possible implication of folate pools during the nitrogen fixation and assimilation, might aid for new engineering targets, in relation to the two transformylations or the production of glycine by serine hydroxymethyl transferase during the de novo purine biosynthetic pathway. In this review, we intend to deliver and discuss the available evidence that support a relevant role of folates during the symbiotic nitrogen fixation. This article is protected by copyright. All rights reserved.

中文翻译：

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豆科植物根瘤中的叶酸

叶酸是植物中的多功能代谢物，对细胞分裂、核酸和氨基酸合成至关重要。在豆科植物的共生固氮过程中，嘌呤从头生物合成需要这些辅助因子，这意味着叶酸库的变化可能直接影响固定氮向植物的流动。其与共生固氮相关的作用尚未探索，但最近的数据表明在第一步中的相关作用。转录组学、代谢组学和蛋白质组学分析表明，叶酸在共生植物组织中积累，因为它们不仅参与嘌呤的从头生物合成，还参与氮易位、核内复制和植物激素生物合成。了解在固氮和同化过程中叶酸池的可能影响，可能有助于新的工程目标，与两个转化或在从头嘌呤生物合成途径中丝氨酸羟甲基转移酶产生甘氨酸有关。在这篇综述中，我们打算提供和讨论支持叶酸在共生固氮过程中的相关作用的现有证据。本文受版权保护。版权所有。