Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches,Journal of Biomedical Materials Research Part A

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Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches
Journal of Biomedical Materials Research Part A ( IF 3.9 ) Pub Date : 2020-09-27 , DOI: 10.1002/jbm.a.37105
Shirin Nour ₁ , Rana Imani ₁ , G Rasul Chaudhry ₂ , Ali Mohammad Sharifi _{3,

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Affiliation

Skin injuries and in particular, chronic wounds, are one of the major prevalent medical problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration, impaired angiogenesis can cause several complications during the wound healing process and skin regeneration. Therefore, induction or promotion of angiogenesis can be considered as a promising approach to accelerate wound healing. This article presents a comprehensive overview of current and emerging angiogenesis induction methods applied in several studies for skin regeneration, which are classified into the cell, growth factor, scaffold, and biological/chemical compound‐based strategies. In addition, the advantages and disadvantages of these angiogenic strategies along with related research examples are discussed in order to demonstrate their potential in the treatment of wounds.

中文翻译：

血管生成靶向组织工程辅助皮肤伤口愈合：生物工程方法的综合回顾

皮肤损伤，特别是慢性伤口，是世界范围内主要的普遍医学问题之一。由于血管生成在组织再生中的关键作用，受损的血管生成会在伤口愈合过程和皮肤再生过程中引起多种并发症。因此，诱导或促进血管生成可以被认为是加速伤口愈合的一种有前途的方法。本文全面概述了当前和新兴的血管生成诱导方法，这些方法应用于多项皮肤再生研究，分为细胞、生长因子、支架和基于生物/化学化合物的策略。此外，

更新日期：2020-09-27

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