Subtle ligand modifications on Ru^II‐polypyridyl complexes may result in different excited‐state characteristics, which provides the opportunity to tune their photo‐physicochemical properties and subsequently change their biological functions. Here, a DNA‐targeting Ru^II‐polypyridyl complex (named Ru1) with highly photosensitizing ³IL (intraligand) excited state was designed based on a classical DNA‐intercalator [Ru(bpy)₂(dppz)]⋅2 PF₆ by incorporation of the dppz (dipyrido[3,2‐a:2′,3′‐c]phenazine) ligand tethered with a pyrenyl group, which has four orders of magnitude higher potency than the model complex [Ru(bpy)₂(dppz)]⋅2 PF₆ upon light irradiation. This study provides a facile strategy for the design of organelle‐targeting Ru^II‐polypyridyl complexes with dramatically improved photobiological activity.

中文翻译：

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靶向具有长寿命3IL激发态的Ru（II）-吡啶基复合物的DNA作为潜在的光动力治疗剂。

Ru ^II-吡啶基配合物的细微配体修饰可能导致不同的激发态特性，这为调节其光物理化学性质并随后改变其​​生物学功能提供了机会。在这里，基于经典的DNA嵌入剂[Ru（bpy）₂（dppz）] ⋅2 PF ₆，设计了具有高光敏性³ IL（配位体）激发态的靶向DNA的Ru ^II-吡啶基复合物（命名为Ru1）。dppz（dipyrido [3,2‐ a：2′，3′‐ c[phen吩嗪]配体与with烯基束缚，在光照射下，pot烯than的效力比模型配合物[Ru（bpy）₂（dppz）] ⋅2 PF ₆高四个数量级。这项研究为设计具有显着改善的光生物学活性的靶向细胞器的Ru ^II-聚吡啶配合物提供了一种简便的策略。