Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model.

动物研究对生物医学研究至关重要，其基石是可复制的动物模型。虽然有许多关于啮齿动物周围神经损伤模型的报道，但大型动物模型对于确认神经再生对人类所需的更长再生距离的影响至关重要。长期以来，猪一直被用作其他外科和生物医学研究的大型动物模型。本文代表了Sus scrofadomestic猪（美国约克夏猪）的一种新型神经血管损伤模型。本文将描述我们在术前、术中和术后方案方面的经验和建议，以及我们为生成有效模型而进行的改进。