Background

The outbreak of COVID-19 caused by SARS-CoV-2 has been a pandemic. The objective of our study was to explore the association between sex and clinical outcomes in patients with COVID-19.

Methods

Detailed clinical data including clinical characteristics, laboratory tests, imaging features and treatments of 1190 cases of adult patients with confirmed COVID-19 were retrospectively analyzed. Associations between sex and clinical outcomes were identified by multivariable Cox regression analysis.

Results

There were 635 (53.4%) male and 555 (46.6%) female patients in this study. Higher rates of acute kidney injury (5.5% vs. 2.9%, p = 0.026), acute cardiac injury (9.1% vs. 4.3%, p = 0.001), and disseminated intravascular coagulation (2.5% vs. 0.7%, P = 0.024) were observed in males. Compared with female patients, male patients with COVID-19 had a higher inhospital mortality rate (15.7% vs. 10.3%, p = 0.005). However, Cox regression analysis showed that sex did not influence inhospital mortality of COVID-19 patients.

Conclusions

Male sex was associated with a worse prognosis of COVID-19, but it seems not to be an independent prognostic factor.

中文翻译：

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COVID-19 患者性别与临床结局的关联：1190 例回顾性分析

背景

由 SARS-CoV-2 引起的 COVID-19 爆发已成为一场大流行。我们研究的目的是探索 COVID-19 患者的性别与临床结果之间的关联。

方法

回顾性分析了1190例确诊的COVID-19成年患者的详细临床数据，包括临床特征、实验室检查、影像学特征和治疗方法。通过多变量 Cox 回归分析确定了性别与临床结果之间的关联。

结果

本研究中有 635 名（53.4%）男性和 555 名（46.6%）女性患者。更高的急性肾损伤（5.5% vs. 2.9%，p = 0.026）、急性心脏损伤（9.1% vs. 4.3%，p = 0.001）和弥散性血管内凝血（2.5% vs. 0.7%，P = 0.024） ) 在男性中观察到。与女性患者相比，男性 COVID-19 患者的住院死亡率更高（15.7%对10.3%，p = 0.005）。然而，Cox 回归分析表明，性别不影响 COVID-19 患者的住院死亡率。

结论

男性与 COVID-19 的预后较差有关，但它似乎不是一个独立的预后因素。