Research question

Does the site of semen collection influence IVF/intracytoplasmic sperm injection (ICSI) cycle outcome?

Design

Retrospective study performed at the University Medical Centre Ljubljana, including all stimulated and modified natural IVF/ICSI cycles (with at least one oocyte retrieved) performed in 2019 with fresh ejaculated semen samples. IVF/ICSI cycle outcomes, in terms of oocytes, embryos and pregnancy rates according to site of semen sample collection (at home or at clinic) were evaluated.

Results

Samples collected at clinic had significantly lower sperm concentration (median [interquartile range, IQR], 50 [20–100] million/ml versus 70 [30–100] million/ml, adjusted odds ratio [OR] 0.001, 95% confidence interval [CI] 1.574 × 10^–6 to 0.196, P = 0.012) and motility (60 [50–70]% versus 70 [50–70]%, adjusted OR 0.034, 95% CI 0.002 to 0.563, P = 0.018, adjusted for age). There was no difference in total sperm count, semen volume or sperm morphology, or women's age (36 [32–39] versus 36 [33–39] years) and men's age (37 [34–41] versus 38 [34–42] years), between semen samples collected at clinic versus at home. When all IVF/ICSI cycles were analysed together using generalized estimating equation analysis, no significant difference in cycle outcomes attributed to site of semen sample collection was observed. There were also no significant differences in cycle outcomes when only first cycles were analysed.

Conclusions

Collecting semen samples at home has a positive effect on sperm quality (sperm concentration and motility were higher), but no significant differences in cycle outcomes are observed when these samples are used in IVF/ICSI cycles. Therefore, it is suggested that collecting semen samples at home for IVF/ICSI procedures is safe and has no negative effect on treatment outcomes.

中文翻译：

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在家收集精液样本进行 IVF/ICSI 不会对新鲜周期的结果产生负面影响

研究问题

精液采集部位是否影响 IVF/卵胞浆内单精子注射 (ICSI) 周期结果？

设计

在卢布尔雅那大学医学中心进行的回顾性研究，包括在 2019 年使用新鲜射出的精液样本进行的所有刺激和改良的自然 IVF/ICSI 周期（至少取回一个卵母细胞）。根据精液样本收集地点（在家或诊所）评估了 IVF/ICSI 周期结果，包括卵母细胞、胚胎和妊娠率。

结果

在诊所收集的样本的精子浓度显着较低（中位数 [四分位距，IQR]，50 [20-100] 百万/ml vs 70 [30-100] 百万/ml，调整后的比值比 [OR] 0.001，95% 置信区间[CI] 1.574 × 10 ^–6至 0.196，P  = 0.012）和运动性（60 [50–70]% 与 70 [50–70]%，调整后 OR 0.034，95% CI 0.002 至 0.563，P = 0.018，根据年龄调整）。精子总数、精液量或精子形态，或女性年龄（36 [32-39] 岁与 36 [33-39] 岁）和男性年龄（37 [34-41] 岁与 38 [34-42] 岁）没有差异] 年），在诊所收集的精液样本与在家收集的精液样本之间。当使用广义估计方程分析一起分析所有 IVF/ICSI 周期时，未观察到归因于精液样本收集部位的周期结果的显着差异。当仅分析第一个周期时，周期结果也没有显着差异。

结论

在家收集精液样本对精子质量有积极影响（精子浓度和活力更高），但当这些样本用于 IVF/ICSI 周期时，没有观察到周期结果的显着差异。因此，建议在家收集精液样本用于 IVF/ICSI 程序是安全的，并且对治疗结果没有负面影响。