Due to the lack of early symptoms and difficulty of accurate diagnosis, ovarian cancer is the most lethal gynecological cancer faced by women. First-line therapy includes a combination of tumor resection surgery and chemotherapy regimen. However, treatment becomes more complex upon recurrence due to development of drug resistance. Drug resistance has been linked to many mechanisms, including efflux transporters, apoptosis dysregulation, autophagy, cancer stem cells, epigenetics, and the epithelial-mesenchymal transition. Thus, developing and choosing effective therapies is exceptionally complex. There is a need for increased specificity and efficacy in therapies for drug-resistant ovarian cancer, and research in targeted nanoparticle delivery systems aims to fulfill this challenge. Although recent research has focused on targeted nanoparticle-based therapies, few of these therapies have been clinically translated. In this review, non-viral nanoparticle delivery systems developed to overcome drug-resistance in ovarian cancer were analyzed, including their structural components, surface modifications, and drug-resistance targeted mechanisms.

由于缺乏早期症状和准确诊断，卵巢癌是女性面临的最致命的妇科癌症。一线治疗包括肿瘤切除手术和化疗方案的组合。然而，由于耐药性的发展，治疗在复发时变得更加复杂。耐药性与许多机制有关，包括外排转运蛋白、细胞凋亡失调、自噬、癌症干细胞、表观遗传学和上皮间质转化。因此，开发和选择有效的疗法异常复杂。需要提高耐药性卵巢癌治疗的特异性和有效性，而靶向纳米颗粒递送系统的研究旨在应对这一挑战。尽管最近的研究集中在基于纳米粒子的靶向疗法，但这些疗法中很少有临床转化。在这篇综述中，分析了为克服卵巢癌耐药而开发的非病毒纳米颗粒递送系统，包括它们的结构成分、表面修饰和耐药靶向机制。