Background

Radiotherapy is one of the most important and common therapies for cancer patients. Selenium has been shown to be capable of reducing the side effects of radiotherapy because selenoproteins have anti-oxidative functions against reactive oxygen species that are induced by the radiation. They also function in DNA-repair and cytokine control.

Purpose

We explored the benefits and risks of selenium supplementation in radiotherapy in our previous review to establish guidelines. In the current study, we expanded the search to cover recent advances in clinical studies of selenium supplementation in radiotherapy.

Methods

We conducted an initial screening in the PubMed using the MeSH terms and keywords “selenium”, “radiation”, “therapy”, and “radiotherapy” using the same methodology applied in our previous review. We identified 121 articles published between January 2013 and December 2019. We then identified eight articles (six studies) on selenium and radiotherapy by excluding 113 articles.

Results

In selenium supplementation studies, selenium doses of 300−500 μg/day with duration of 10 days to 6 months were used. Selenium supplementation improved the selenium nutritional conditions of the patients and reduced the side effects of radiotherapy. Selenium supplementation did not reduce the effectiveness of radiotherapy, and no toxicities were reported.

Conclusion

The results of our previous and current reviews showed that selenium supplementation offers specific benefits for several cancer types treated with radiotherapy. Here, we suggest a new guideline for selenium supplementation in radiotherapy. We recommend determining the selenium status of the patients before radiotherapy, and in cases of deficiency (<100 μg/L serum selenium level), selenium supplement can be beneficial.

中文翻译：

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放疗补硒临床研究新进展

背景

放射治疗是癌症患者最重要和最常见的治疗方法之一。硒已被证明能够减少放疗的副作用，因为硒蛋白具有抗氧化功能，可对抗由辐射诱导的活性氧。它们还在 DNA 修复和细胞因子控制中起作用。

目的

我们在之前的综述中探讨了在放射治疗中补充硒的益处和风险，以制定指南。在当前的研究中，我们扩大了搜索范围，以涵盖放射治疗中硒补充临床研究的最新进展。

方法

我们使用 MeSH 术语和关键字“硒”、“放射”、“治疗”和“放射治疗”在 PubMed 中进行了初步筛选，使用的方法与我们之前审查中应用的方法相同。我们确定了 2013 年 1 月至 2019 年 12 月期间发表的 121 篇文章。然后我们通过排除 113 篇文章确定了 8 篇关于硒和放疗的文章（6 项研究）。

结果

在硒补充研究中，硒剂量为 300-500 μg/天，持续时间为 10 天至 6 个月。补硒改善了患者的硒营养状况，减少了放疗的副作用。硒补充剂不会降低放射治疗的有效性，也没有报告毒性。

结论

我们之前和当前的审查结果表明，硒补充剂对几种接受放疗的癌症类型具有特定的益处。在这里，我们提出了一个新的放射治疗硒补充指南。我们建议在放疗前确定患者的硒状态，在缺乏（<100 μg/L 血清硒水平）的情况下，补充硒可能是有益的。