In this study, polymer-ceramic nanocomposites and/or composites were prepared by solution removal method using poly(methylmethacrylat) (PMMA) and nano-hydroxyapatite (nHA). They were characterized using X-ray diffraction (XRD), Fourier transform infrared-attenuated total reflection spectroscopy (FTIR-ATR), and differential thermal analysis/thermogravimetry (DTA/TG). Their effects and biocompatibilities on antioxidant enzymes were also investigated in detail. It has been shown that nHA was dramatically dispersed at nanoscale in the polymer matrix. The interaction occurred between OH groups of nHA and carbonyl groups of polymer and introduction of ceramic into the polymer matrix generally resulted in an increase in thermal stability. Nanocomposites and composites had different effects on enzyme activities. Samples synthesized in acetone increased enzyme activities for glutathione reductase (GR) and glucose-6 phosphate dehydrogenase (G6PD) enzymes, while inhibiting glutathione peroxidase (GPx) and catalase (CAT) enzyme activities. On the other hand, samples synthesized in tetrahydrofuran (THF) exhibited inhibitory behavior for G6PD and CAT enzymes. The samples synthesized in different media did not show any regularity on enzyme activities. The nanocomposites and/or composites prepared in acetone media were better hemocompatible than those in THF.

中文翻译：

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PMMA/羟基磷灰石纳米复合材料/复合材料对抗氧化酶的影响

在这项研究中，使用聚甲基丙烯酸甲酯 (PMMA) 和纳米羟基磷灰石 (nHA) 通过溶液去除法制备聚合物-陶瓷纳米复合材料和/或复合材料。使用 X 射线衍射 (XRD)、傅里叶变换红外衰减全反射光谱 (FTIR-ATR) 和差热分析/热重分析 (DTA/TG) 对其进行表征。还详细研究了它们对抗氧化酶的影响和生物相容性。已经表明，nHA 以纳米级显着分散在聚合物基质中。nHA 的 OH 基团和聚合物的羰基之间发生相互作用，将陶瓷引入聚合物基体通常会增加热稳定性。纳米复合材料和复合材料对酶活性有不同的影响。在丙酮中合成的样品增加了谷胱甘肽还原酶 (GR) 和葡萄糖 6 磷酸脱氢酶 (G6PD) 的酶活性，同时抑制了谷胱甘肽过氧化物酶 (GPx) 和过氧化氢酶 (CAT) 的酶活性。另一方面，在四氢呋喃 (THF) 中合成的样品表现出对 G6PD 和 CAT 酶的抑制行为。在不同培养基中合成的样品在酶活性方面没有表现出任何规律性。在丙酮介质中制备的纳米复合材料和/或复合材料比在 THF 中制备的具有更好的血液相容性。在不同培养基中合成的样品在酶活性方面没有表现出任何规律性。在丙酮介质中制备的纳米复合材料和/或复合材料比在 THF 中制备的具有更好的血液相容性。在不同培养基中合成的样品在酶活性方面没有表现出任何规律性。在丙酮介质中制备的纳米复合材料和/或复合材料比在 THF 中制备的具有更好的血液相容性。