The behavioral changes, including spatial learning and memory impairment as well as depressive- and anxiety-like behaviors in an animal model of asthma were demonstrated previously. On the other hand, there is increasing evidence that the anti-inflammatory actions of exercise are related to their neuroprotective properties against different insults in the brain. This study was aimed to explore the effects of moderate treadmill exercise on cognitive deficits and possible anti-inflammatory mechanisms in ovalbumin (OVA)-sensitized rats. The exercise groups were trained to run on the treadmill 30 min/day with an intensity of 12 m/min, 5 days/week for 4 weeks. Animals in the OVA groups were sensitized by two intraperitoneal (i.p.) injections of OVA (10 μg/injection) and challenged with OVA by inhalation during the treadmill running exercise period. Passive avoidance (PA) memory, levels of interleukin (IL)-10 and tumor necrosis factor (TNF)-α in the hippocampus, total and differential white blood cell (WBC) count in the blood as well as pathological changes of the lung were then evaluated. OVA-sensitization was resulted in cognitive deficits in the PA task, along with increased total and differential WBC in blood and TNF-α in the hippocampus. However, exercise ameliorated these changes and increased the IL-10 level in the hippocampus, suggesting that moderate treadmill exercise can improve memory impairment in OVA-sensitized rats due to its anti-inflammatory properties.

先前已经证明了哮喘动物模型中的行为变化，包括空间学习和记忆障碍以及抑郁和焦虑样行为。另一方面，越来越多的证据表明，运动的抗炎作用与其对大脑中不同损伤的神经保护特性有关。本研究旨在探讨适度跑步机运动对卵清蛋白 (OVA) 致敏大鼠认知缺陷和可能的抗炎机制的影响。运动组训练在跑步机上跑步 30 分钟/天，强度为 12 米/分钟，每周 5 天，持续 4 周。OVA 组中的动物通过两次腹膜内 (ip) 注射 OVA（10 μg/注射）致敏，并在跑步机跑步锻炼期间通过吸入 OVA 进行攻击。被动回避（PA）记忆，海马白细胞介素（IL）-10和肿瘤坏死因子（TNF）-α水平，血液中白细胞（WBC）总数和分类计数以及肺部病理变化。然后评价。OVA 致敏导致 PA 任务中的认知缺陷，以及血液中的总和差异 WBC 和海马中的 TNF-α 增加。然而，运动改善了这些变化并增加了海马中的 IL-10 水平，表明适度的跑步机运动可以改善 OVA 致敏大鼠的记忆障碍，因为它具有抗炎特性。然后评估血液中的总和分类白细胞 (WBC) 计数以及肺的病理变化。OVA 致敏导致 PA 任务中的认知缺陷，以及血液中的总和差异 WBC 和海马中的 TNF-α 增加。然而，运动改善了这些变化并增加了海马中的 IL-10 水平，表明适度的跑步机运动可以改善 OVA 致敏大鼠的记忆障碍，因为它具有抗炎特性。然后评估血液中的总和分类白细胞 (WBC) 计数以及肺的病理变化。OVA 致敏导致 PA 任务中的认知缺陷，以及血液中的总和差异 WBC 和海马中的 TNF-α 增加。然而，运动改善了这些变化并增加了海马中的 IL-10 水平，表明适度的跑步机运动可以改善 OVA 致敏大鼠的记忆障碍，因为它具有抗炎特性。