To investigate the association between alcohol intake pattern in amount and frequency and metabolic syndrome (Mets) components, we simulated the change in the prevalence of Mets components by intake reduction. In order to manage Mets, alcohol intake reduction with moderation of intake pattern is required. However, evidence investigating the comparative impact of alcohol intake reduction in amount and frequency for Mets components is limited. We conducted a large-scale cross-sectional study in the general Japanese population. The study subjects included 37,371 non-drinkers and current drinkers recruited in the Japan Multi-Institutional Collaborative Cohort Study. Odds ratios (ORs) for Mets components according to alcohol intake amount and frequency were estimated using a multiple logistic regression model. The prevalence of Mets components was estimated after assumed alcohol intake reduction of a) none, b) 10 g/day (men) or 5 g/day (women), c) 20 g/day (men) or 10 g/day (women), d) less than 20 g/day (men) or 10 g/day (women) for moderate-to-heavy drinkers, e) 1–2 times/week, and f) 3–4 times/week. The ORs with alcohol intake amount and frequency increased with high blood pressure while decreasing with dyslipidemia. A J-shaped association was observed between intake amount and Mets. The estimated prevalence (%) of high blood pressure and dyslipidemia in men were a) 45.2, b) 43.0, c) 41.4, d) 40.4, e) 42.9, and f) 42.0; and a) 50.3, b) 51.8, c) 52.9, d) 50.2, e) 52.7, and f) 53.4 in women. The estimated prevalence of high blood pressure in women did not evidently decrease. Simulated alcohol intake reduction showed decreased prevalence for high blood pressure and increased prevalence for dyslipidemia in men after reduced intake amount and frequency. The largest decreased prevalence for high blood pressure was observed in men when all moderate-to-heavy drinkers reduced their alcohol intake amount to less than 20 g/day.

为了研究酒精摄入量和频率与代谢综合征 (Mets) 成分之间的关​​联，我们通过减少摄入量模拟了 Mets 成分流行率的变化。为了管理 Mets，需要通过适度的摄入模式来减少酒精摄入量。然而，研究酒精摄入量减少对 Mets 成分的比较影响的证据是有限的。我们在日本一般人群中进行了大规模横断面研究。研究对象包括在日本多机构协作队列研究中招募的 37,371 名不饮酒者和当前饮酒者。使用多元逻辑回归模型估计根据酒精摄入量和频率的 Mets 成分的优势比 (OR)。在假设酒精摄入量减少 a) 无，b) 10 克/天（男性）或 5 克/天（女性），c）20 克/天（男性）或 10 克/天（女性），d）中度至重度饮酒者少于 20 克/天（男性）或 10 克/天（女性），e) 1-2 次/周，和 f) 3-4 次/周。饮酒量和饮酒频率的 ORs 随高血压升高而升高，随血脂异常升高而降低。在摄入量和 Mets 之间观察到 J 形关联。男性高血压和血脂异常的估计患病率 (%) 为 a) 45.2、b) 43.0、c) 41.4、d) 40.4、e) 42.9 和 f) 42.0；a) 50.3、b) 51.8、c) 52.9、d) 50.2、e) 52.7 和 f) 53.4 女性。女性高血压的估计患病率并没有明显下降。模拟酒精摄入量减少显示，在减少摄入量和频率后，男性高血压患病率降低，血脂异常患病率增加。当所有中度至重度饮酒者将其酒精摄入量减少到 20 克/天以下时，男性的高血压患病率下降幅度最大。