Although Meyerozyma guilliermondii complex is an uncommon cause of invasive candidiasis worldwide, reported cases, mainly regarding bloodstream infections, increased over years, and patients with cancer who have undergone recent surgery are most commonly affected. However, the clinical characteristics and outcomes of candidemia caused by M. guilliermondii complex remain poorly understood. A retrospective case–control study was conducted to evaluate the clinical characteristics and mortality of candidemia caused by M. guilliermondii complex in cancer patients undergoing surgery. Demographic and clinical data were collected from the hospital medical records system with a standardized data collection form and were analyzed with SPSS 20.0. Sixty-six cancer patients who have undergone recent surgery and were diagnosed with candidemia caused by M. guilliermondii complex were included in the study. Regarding the clinical manifestations, most patients’ body temperatures ranged from 38 to 40 °C, with a median fever duration of 4 (IQR: 3–6) days. Multivariate analysis indicated that the presence of central venous catheter (OR: 6.68; 95% CI 2.80–15.94) and gastric tube (OR: 3.55; 95% CI 1.22–10.34) were independent risk factors for M. guilliermondii complex fungemia. The 30-day crude mortality of candidemia caused by M. guilliermondii complex was 12.1%, twice that of the control group. Moreover, increased WBC count, age ≥ 60 years, septic shock, and ICU admission were identified as predictors of mortality through univariate analysis. These findings will provide a foundation for the clinical management of candidemia caused by M. guilliermondii complex in post-surgical cancer patients.

尽管Meyerozyma guilliermondii复合体是世界范围内侵袭性念珠菌病的罕见原因，但报告的病例（主要是血流感染）逐年增加，最近接受过手术的癌症患者最常受到影响。然而，由M. guilliermondii复合体引起的念珠菌血症的临床特征和结果仍然知之甚少。进行了一项回顾性病例对照研究，以评估由M. guilliermondii引起的念珠菌血症的临床特征和死亡率接受手术的癌症患者的复杂性。人口统计学和临床​​数据采用标准化的数据采集表从医院病历系统中收集，并用SPSS 20.0进行分析。该研究包括了66 名最近接受过手术并被诊断患有由M. guilliermondii复合体引起的念珠菌血症的癌症患者。在临床表现方面，大多数患者的体温在 38 至 40°C 之间，中位发热持续时间为 4（IQR：3-6）天。多变量分析表明，中心静脉导管（OR：6.68；95% CI 2.80–15.94）和胃管（OR：3.55；95% CI 1.22–10.34）是吉列蒙氏分枝杆菌复杂真菌血症的独立危险因素。由以下因素引起的念珠菌血症的 30 天粗死亡率M. guilliermondii复合体为 12.1%，是对照组的两倍。此外，通过单变量分析，白细胞计数增加、年龄≥60 岁、感染性休克和入住 ICU 被确定为死亡率的预测因子。这些发现将为手术后癌症患者由M. guilliermondii复合体引起的念珠菌血症的临床管理提供基础。