Nanocrystals (NCs) are the class of solid dosage forms which utilizes the concept of nanoscience together with crystal nature of drug to achieve advantages in terms of solubility, dissolution, and physicochemical properties. Comparing with other solid dosage forms, NC often comes with so many challenges in terms of physical stability as well as chemical stability during the manufacturing process and storage. Therefore, physicochemical properties of nanocrystals, toxic effect on the human body, and application in drug delivery through the various routes of administration are critical step formulation of NCs. There are various techniques involved to ensure solid state uniformity in the NCs and its impact on therapeutic performance. This review article emphasizes on various solid-state characterization techniques that are used to evaluate NCs, their toxicity, and pharmaceutical application. Further, NC-based marketed formulation is also discussed in this review.

纳米晶体（NCs）是一类固体剂型，它利用纳米科学的概念以及药物的晶体性质来获得溶解度，溶解度和物理化学性质方面的优势。与其他固体剂型相比，NC在制造过程和存储过程中的物理稳定性以及化学稳定性方面经常面临许多挑战。因此，纳米晶体的理化特性，对人体的毒性作用以及通过各种给药途径在药物递送中的应用是NC的关键步骤。有多种技术可以确保NC中的固态均匀性及其对治疗性能的影响。这篇评论文章重点介绍了用于评估NC的各种固态表征技术，它们的毒性以及药物应用。此外，本评论还讨论了基于NC的市场化配方。