Background

1, 3-Butadiene is an important industrial compound. Based on sufficient evidence of carcinogenicity in laboratory animals and humans, the International Agency for Research on Cancer, in 1999, classified 1, 3-Butadiene as a probable carcinogen to humans (group 2A). The potential for exposure to vehicle exhaust containing these chemical compounds is very noticeable in urban locations. Exposure to incomplete combustion of gasoline has been a long time concern in many occupational fields, including policemen, service stations, and the petroleum industry but in Iran has rarely been studied.

Methods

This study designed to determine the exposure levels for traffic policemen and gas station workers during routine work shift, by biological monitoring. With this aim, 25 policemen engaged in traffic control, 25 gas station workers and 25 occupationally non-exposed persons were investigated. Spot urine samples were obtained prior to and at the end of the work shift from each subject. The urinary levels of selected urinary metabolites (MHBMA and DHBMA) were determined by using LC–MS/MS.

Results

There were significant differences among the mean urinary concentrations of DHBMA in pre-shift samples of policemen, gas station workers and occupationally non-exposed persons. The mean urinary concentrations of DHBMA differed significantly among post-shift samples of policemen and gas station (ANOVA: p < 0.05 and Kruskal-Wallis test: p < 0.05).

Conclusions

There was a significant difference in DHBMA concentrations between job categories (p < 0.05 by ANOVA and Kruskal-Wallis test), and policemen and gas station workers were found to be probably the most exposed groups in this study.

中文翻译：

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1.3 丁二烯暴露评估中生物监测的应用

 背景

1, 3-丁二烯是一种重要的工业化合物。基于实验室动物和人类致癌性的充分证据，国际癌症研究机构于 1999 年将 1, 3-丁二烯列为可能对人类致癌的物质（2A 类）。在城市地区，接触含有这些化合物的汽车尾气的可能性非常明显。暴露于汽油不完全燃烧一直是许多职业领域（包括警察、加油站和石油工业）长期关注的问题，但在伊朗却很少进行研究。

 方法

本研究旨在通过生物监测确定交通警察和加油站工作人员在日常轮班期间的暴露水平。为此，对25名从事交通管制的警察、25名加油站工作人员和25名职业非暴露人员进行了调查。在轮班之前和轮班结束时从每个受试者身上采集点尿样本。使用 LC-MS/MS 测定选定尿代谢物（MHBMA 和 DHBMA）的尿水平。

 结果

警察、加油站工作人员和非职业接触者的轮班前样本中DHBMA平均尿浓度存在显着差异。警察和加油站的轮班后样本中 DHBMA 的平均尿液浓度存在显着差异（方差分析：p < 0.05 和 Kruskal-Wallis 检验：p < 0.05）。

 结论

不同工作类别之间的 DHBMA 浓度存在显着差异（方差分析和 Kruskal-Wallis 检验 p < 0.05），并且发现警察和加油站工作人员可能是本研究中暴露程度最高的群体。