The protective mechanisms of specific antibodies against tick-borne encephalitis virus were demonstrated on in vitro model. The effect of specific IgG on tick-borne encephalitis virus was comprehensively assessed in virucidal, preventive, direct antiviral, and intracellular actions by ELISA and virus titration results. The IC50 values were obtained for virucidal (3.8±0.7 U/ml), preventive (42.8±9.9 U/ml), direct antiviral (7.2±0.9 U/ml), and intracellular action (1.7±0.4 U/ml). During titration of the samples, complete elimination of the virus was observed at IgG concentration of 16 U/ml (virucidal), 320 U/ml (preventive), 32 U/ml (direct antiviral), and 8 U/ml (intracellular action). It was demonstrated that specific IgG produces a complex inhibitory effect on tick-borne encephalitis virus: it possesses both direct neutralizing activity on the virus and reduces its adsorption and intracellular replication.

中文翻译：

---

特异性抗体对蜱传脑炎病毒的保护作用机制

在体外模型上证明了针对蜱传脑炎病毒的特异性抗体的保护机制。通过ELISA和病毒滴定结果，在杀病毒、预防、直接抗病毒和细胞内作用方面综合评估了特异性IgG对蜱传脑炎病毒的影响。获得了杀病毒 (3.8±0.7 U/ml)、预防 (42.8±9.9 U/ml)、直接抗病毒 (7.2±0.9 U/ml) 和细胞内作用 (1.7±0.4 U/ml) 的 IC50 值。在样品滴定期间，在 16 U/ml（杀病毒）、320 U/ml（预防）、32 U/ml（直接抗病毒）和 8 U/ml（细胞内作用）的 IgG 浓度下观察到病毒完全消除）。已证明特异性 IgG 对蜱传脑炎病毒产生复杂的抑制作用：