We studied the expression of sirtuin 1 (Sirt1) in the dorsomedial and ventromedial nuclei of the hypothalamus in young (2 months) and old (2 years) rats by immunohistochemical methods and Western blotting. In aged males and females, a decrease in Sirt1 expression in dorsomedial nucleus was observed. In ventromedial nucleus, the expression of Sirt1 did not change with age. The results confirm the hypothesis that aging is associated with a decrease in the content of sirtuins in the hypothalamic nuclei.

中文翻译：

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Sirtuin 1 在衰老过程中大鼠腹内侧和背内侧下丘脑核的表达

我们通过免疫组织化学方法和蛋白质印迹研究了年轻（2 个月）和年老（2 岁）大鼠下丘脑背内侧和腹内侧核中 Sirtuin 1 (Sirt1) 的表达。在老年男性和女性中，观察到背内侧核中 Sirt1 表达的减少。在腹内侧核中，Sirt1的表达不随年龄变化。结果证实了衰老与下丘脑细胞核中sirtuins含量减少有关的假设。