We analyzed biodistribution of 68Ga-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in Wistar rats with experimental model of bone callus. It was shown that the content of 68Ga-DTPMP and 68Ga-HEDP in bone callus was ~1.5-fold higher than in intact femur. 68Ga-DTPMP was characterized by higher stability in vivo, higher uptake in the bone tissue, and lower uptake in others visceral organs in comparison with 68Ga-HEDP. Thus, 68Ga-DTPMP had more suitable pharmacokinetic properties than 68Ga-HEDP.

中文翻译：

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68镓标记双膦酸和五膦酸在大鼠骨愈伤组织模型中的药代动力学对比研究

我们分析了 68Ga 标记的羟亚乙基二膦酸 (68Ga-HEDP) 和二亚乙基三胺五(亚甲基膦酸) (68Ga-DTPMP) 在具有骨愈伤组织实验模型的 Wistar 大鼠中的生物分布。结果表明，骨愈伤组织中 68Ga-DTPMP 和 68Ga-HEDP 的含量比完整股骨高约 1.5 倍。与 68Ga-HEDP 相比，68Ga-DTPMP 具有更高的体内稳定性、更高的骨组织摄取和更低的其他内脏器官摄取。因此，68Ga-DTPMP 比 68Ga-HEDP 具有更合适的药代动力学特性。