The present study analyzed diffusion characteristics of white matter tracts and grey matter anatomy in 48 mentally healthy participants, including first-degree relatives of patients with schizophrenia (N=13) and affective spectrum disorders (N=13). The subgroup with familial risk of schizophrenia displayed abnormalities in the structural connectivity and increased cortical thickness in the superior frontal gyrus. No differences in the analyzed characteristics were revealed in the subgroup with familial risk for affective disorders. The results are discussed within the framework of the concepts of endophenotypes and processes reflecting compensatory and protective mechanisms.

中文翻译：

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传导束的多模态 MRI 和脑灰质解剖在家族性情感障碍和精神分裂症风险中的作用

本研究分析了 48 名精神健康参与者的白质束和灰质解剖结构的弥散特征，包括精神分裂症（N=13）和情感谱系障碍（N=13）患者的一级亲属。具有精神分裂症家族风险的亚组表现出结构连接异常和额上回皮质厚度增加。在具有情感障碍家族风险的亚组中，所分析的特征没有显示差异。结果在反映补偿和保护机制的内表型和过程概念的框架内进行了讨论。