Leukemia is the outcome of aggregation of damaged white blood cells. Several genes were reported to be associated with the pathogenesis of leukemia. These genes were computationally analyzed to decipher their codon usage bias (CUB) and to identify the prime factors influencing the codon usage profile as no work was reported yet. The mean values of synonymous codon usage order (SCUO) parameter indicated low CUB of the genes. Significant positive association of SCUO with overall GC and positional GCs might signal the presence of mutational pressure. However, neutrality plot suggested the dominant role of natural selection across the genes. Along with natural selection, the role of mutation pressure was also prominent and that might be responsible for lower CUB (SCUO = 0.19) of genes. Low translational speed might permit accuracy in the process. A strong inverse relationship of translational rate was observed with CUB of genes and folding energy.

白血病是受损白细胞聚集的结果。据报道有几个基因与白血病的发病机制有关。对这些基因进行了计算分析，以破译其密码子使用偏倚（CUB）并确定影响密码子使用情况的主要因素，因为尚无报道。同义密码子使用顺序（SCUO）参数的平均值表明基因的CUB较低。SCUO与整体GC和位置GC的显着正相关可能表明存在突变压力。但是，中性图表明了基因间自然选择的主导作用。除自然选择外，突变压力的作用也很突出，这可能导致基因的CUB降低（SCUO = 0.19）。低的平移速度可能会提高过程的准确性。