Beiging of white adipose tissue has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how it is regulated deserve more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous white adipose tissue (scWAT) responded to cold stimulation and was able to promote mobilization of triglyceride. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1's products-oleic acid. Oleic acid upregulated lipases ATGL and HSL expression. When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation was increased. These effects were also demonstrated by the SCD1 knockdown experiments in mice. In conclusion, our study suggests that SCD1, known as an enzyme for lipid synthesis, plays a role in up-regulating lipid mobilization through its desaturation product oleic acid.

中文翻译：

---

SCD1 促进皮下白色脂肪组织中的脂质动员。


白色脂肪组织对新陈代谢有有益的影响。尽管已知米色脂肪细胞在脂质分解代谢和生热作用中活跃，但其调节方式值得更多探索。在这项研究中，我们证明皮下白色脂肪组织 (scWAT) 中的硬脂酰辅酶 A 去饱和酶 1 (SCD1) 对冷刺激有反应，并且能够促进甘油三酯的动员。体外研究表明，SCD1 促进 C3H10T1/2 白色脂肪细胞的脂肪分解。脂肪分解作用是由SCD1的产物之一——油酸贡献的。油酸上调脂肪酶 ATGL 和 HSL 的表达。当SCD1在小鼠scWAT中过度表达时，脂肪分解增强，耗氧量和产热增加。这些效应也通过小鼠 SCD1 敲低实验得到了证实。总之，我们的研究表明，SCD1（一种脂质合成酶）通过其去饱和产物油酸在上调脂质动员中发挥作用。