Enantioselective Arylcyanation of Styrenes via Copper‐Catalyzed Radical Relay†,Chinese Journal of Chemistry

当前位置： X-MOL 学术 › Chin. J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective Arylcyanation of Styrenes via Copper‐Catalyzed Radical Relay†
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-09-27 , DOI: 10.1002/cjoc.202000494
Weiwen Zhuang ₁ , Pinhong Chen ₁ , Guosheng Liu _{1,

2}

Affiliation

The first copper‐catalyzed enantioselective arylcyanation of styrenes has been developed using readily available anilines as aryl radical precursors under mild conditions, which enables easy access to chiral 2,3‐diaryl propionitriles with moderate to good enantioselectivities. This operationally straightforward reaction exhibits broad substrate scope and functional group tolerance. Notably, this method has been applied to the synthesis of chiral AIEgen as well as estrogen receptor‐β agonist (R)‐diarylpropionitrile (DPN).

中文翻译：

铜催化自由基继电器对苯乙烯的对映选择性芳基氰化†

在温和的条件下，使用容易获得的苯胺作为芳基自由基前体开发了苯乙烯的第一个铜催化的对映选择性芳基氰化反应，这使得容易获得具有中等至良好对映选择性的手性2,3-二芳基丙腈。该操作简单的反应显示出广泛的底物范围和官能团耐受性。值得注意的是，该方法已应用于手性AIEgen以及雌激素受体-β激动剂（R）-二芳基丙腈（DPN）的合成。

更新日期：2020-09-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11