Better intervention strategies for patients with treatment‐resistant depression are greatly needed. McIntyre and colleagues¹ set out to investigate the effectiveness of intravenous (IV) ketamine through a chart review of 201 such outpatients that all received four IV ketamine infusions over one‐to‐two weeks. They concluded that IV ketamine was effective in treating anxiety, irritability, agitation (AIA) and suicidal ideation (SI) in adults with treatment‐resistant mood disorders and suggested IV ketamine should be considered a treatment alternative for adults with affective disorders presenting with mixed features in addition to suggesting a need for a randomized trial based on their findings.

中文翻译：

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回顾性研究没有证据表明静脉注射氯胺酮治疗抵抗性情绪障碍的有效性

急需对耐药性抑郁症患者采取更好的干预策略。McIntyre及其同事¹着手通过对201位此类门诊患者进行图表审查来调查静脉内（氯）氯胺酮的有效性，这些患者在^1-2周内全部接受了四次IV氯胺酮输注。他们得出结论，静脉注射氯胺酮可有效治疗患有抗药性情绪障碍的成年人的焦虑，烦躁，躁动（AIA）和自杀意念（SI），并建议静脉注射氯胺酮应被视为具有混合特征的情感障碍成年人的治疗选择除了建议根据他们的发现进行随机试验外。