Molecular Diversity ( IF 3.9 ) Pub Date : 2020-09-27 , DOI: 10.1007/s11030-020-10145-8 Mohd Nazeef 1 , Km Neha Shivhare 1 , Shabir Ali 2 , Saif Ansari 1 , I R Siddiqui 1
|
Abstract
A new metal-free approach to construct medicinally valuable 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles under visible light irradiation in aqueous ethanol medium at room temperature has been developed. The present process was performed with 1,2-phenylenediamines, aromatic aldehydes and 2-mercaptoacetic acid utilizing a simple household 22 W compact fluorescent lamp to generate C–S, C–N bonds through radical intermediates. This visible-light-promoted synthesis provides lower cost, operation simplicity and high functional groups tolerating ability with short reaction time and high yield under mild reaction conditions.
Graphic abstract
中文翻译：
可见光介导的一锅法有效合成1-芳基-1H,3H-噻唑并[3,4-a]苯并咪唑：一种在乙醇水溶液中的无金属光化学方法。
抽象的
开发了一种新的无金属方法，在室温下在水性乙醇介质中可见光照射下构建具有药用价值的1-芳基-1H , 3H-噻唑并[3,4 -a ]苯并咪唑。本过程使用 1,2-苯二胺、芳香醛和 2-巯基乙酸，使用简单的家用 22 W 紧凑型荧光灯通过自由基中间体生成 C-S、C-N 键。这种可见光促进的合成成本较低，操作简单，官能团耐受能力强，反应时间短，反应条件温和，收率高。
京公网安备 11010802027423号