Skin wound healing involves a coordinated cellular response to achieve complete reepithelialization. Elevated levels of reactive oxygen species (ROS) in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing process. Herein, cerium oxide nanoparticles (CeNPs) matrices like nanofibers have also been explored for enhancing wound healing. In this work, we have established the fabrication of CeNPs functionalized gelatin polycaprolactone (PCL) nanofibers (PCLNF) and CeNPs laden with PCL nanofiber (PCLNPNF) matrices by the electrospun methods. The bioactive composition PCLNPNF maintained the fiber morphological behaviour for up to 15 days. Further, the PCLNPNF matrices enhanced the cell proliferation against the NIH-3T3 cell lines established by Alamar blue assay. Furthermore, the PCLNPNF matrices scavenged ROS property examined with DCFH-DA intensity of the fluorescence microscopy. The antibacterial property of the PCLNPNF shows the remarkable activity against the gram-positive (S. aureus), and gram-negative (P. aeruginosa). Additionally, the in vivo bacterial removals and invented wound injuries examined development were definite through the MRSA-infects mice model. Taking to the advantages of this work, the newly fabricated PCLNPNF is a promising antibiotic alternative to battle the various bacterial infections in future.

皮肤伤口愈合涉及协调的细胞反应，以实现完全的再上皮化。伤口环境中活性氧（ROS）水平升高通常会阻碍伤口愈合，导致伤口愈合过程受损。在本文中，还研究了氧化铈纳米颗粒（CeNPs）基质（如纳米纤维）以增强伤口愈合。在这项工作中，我们通过电纺方法建立了CeNPs功能化明胶聚己内酯（PCL）纳米纤维（PCLNF）和载有PCL纳米纤维（PCLNPNF）基质的CeNPs的制造。生物活性组合物PCLNPNF保持纤维形态行为长达15天。此外，PCLNPNF基质增强了针对通过Alamar蓝分析建立的NIH-3T3细胞系的细胞增殖。此外，用荧光显微镜的DCFH-DA强度检查PCLNPNF基质清除了ROS特性。PCLNPNF的抗菌性能显示出对革兰氏阳性（金黄色葡萄球菌（S. aureus）和革兰氏阴性（P. aeruginosa）。另外，通过MRSA感染小鼠模型确定了体内细菌清除和发明伤口损伤的发展。利用这项工作的优势，新制造的PCLNPNF是一种有前途的抗生素替代品，可以应对未来的各种细菌感染。