Abnormalities in lipid metabolism are commonly observed in patients who were obese. Alongside dyslipidemia, one of the markers in predicting the risk of cardiovascular disease is the Atherogenic Index of Plasma (AIP), which is related to dietary intake. Healthy fat quality indices might affect on AIP. The purpose of this study is to find the possible relationship between dietary fat quality, and AIP and comparison of these indices among obese and non-obese volunteers. This study was a cross-sectional descriptive-analytic case-control study with 157 normal and overweight and obese volunteers (n = 71 normal, Age: 38.90 ± 10.976 vs n = 86 overweight/obese, Age: 38.60 ± 9.394) in the age range of 18–65 years. Food intake was measured using FFQ, anthropometric indices (weight, height, body mass index and waist to hip ratio), body composition (visceral fat level, total body water, body fat mass), and lipid profile were measured. Based on the present results, comparable biochemical parameters including TC (P = 0.580), TG (P = 0.362), LDL (P = 0.687) and HDL (P = 0.151) among overweight/obese volunteers as compared to normal ones were noticed. Effects of dietary fat quality, including Atherogenicity (AI) and Thrombogenicity (TI) hypo/hypercholesterolemic ratio (h/H), the Cholesterol-Saturated Fat Index (CSI) showed significantly higher AI (P = 0.012) in the overweight/obese group as compared to the normal group. Whereas, h/H (P = 0.034) and ω-6/ω-3 ratio (P = 0.004) were significantly higher in normal-weight volunteers. There was a positive correlation between AI, TI, CSI, SFA, MUFA, PUFA and ω-6/ω-3 ratio with AIP and negative correlation between h/H with AIP in both groups. Despite the significances of these correlations no strong relation was observed by doing multiple regression among normal and overweight/obese groups (R2 = 0.210, R2 = 0.387). In summary, the present work proposes a direct relationship between dietary fat quality, increased BMI, and lipid abnormalities with AIP. Nevertheless, further large-scale studies are required to sustain a clear conclusion in this wish.

中文翻译：

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肥胖和非肥胖志愿者膳食脂肪质量指数和血脂谱与血浆致动脉粥样硬化指数之间的相关性：横断面描述性分析病例对照研究


肥胖患者通常会出现脂质代谢异常。除了血脂异常之外，预测心血管疾病风险的标志之一是血浆致动脉粥样硬化指数 (AIP)，该指数与饮食摄入量有关。健康脂肪质量指数可能会影响 AIP。本研究的目的是寻找膳食脂肪质量与 AIP 之间可能的关系，并比较肥胖和非肥胖志愿者的这些指数。本研究是一项横断面描述性分析病例对照研究，共有 157 名正常、超重和肥胖志愿者（n = 71 名正常人，年龄：38.90 ± 10.976 vs n = 86 名超重/肥胖，年龄：38.60 ± 9.394）。年龄范围为 18-65 岁。使用FFQ测量食物摄入量，测量人体测量指数（体重、身高、体重指数和腰臀比）、身体成分（内脏脂肪水平、体内总水分、身体脂肪量）和血脂状况。根据目前的结果，超重/肥胖志愿者与正常志愿者相比，发现了可比较的生化参数，包括 TC (P = 0.580)、TG (P = 0.362)、LDL (P = 0.687) 和 HDL (P = 0.151)。膳食脂肪质量的影响，包括致动脉粥样硬化性 (AI) 和血栓形成性 (TI)、低/高胆固醇比率 (h/H)、胆固醇饱和脂肪指数 (CSI)，显示超重/肥胖组的 AI 显着较高 (P = 0.012)与正常组相比。然而，正常体重志愿者的 h/H (P = 0.034) 和 ω-6/ω-3 比率 (P = 0.004) 显着较高。两组中AI、TI、CSI、SFA、MUFA、PUFA及ω-6/ω-3比值与AIP呈正相关，h/H与AIP呈负相关。 尽管这些相关性很重要，但通过在正常组和超重/肥胖组之间进行多元回归，没有观察到很强的相关性（R2 = 0.210，R2 = 0.387）。总之，目前的工作提出膳食脂肪质量、BMI 增加和脂质异常与 AIP 之间存在直接关系。然而，还需要进一步的大规模研究来维持这一愿望的明确结论。