Theses reviewed in this issue include “Engineering Efficient and Safe In Situ Genome Regulation via CRISPR-Cas9 for Enabling Gene Therapies,” “Investigating the Mechanism of LINE-1 Retrotransposition in Human Cells,” “Machine Learning Approaches for Prediction of Kidney Transplant Survival,” “Novel Obesity Suppressor Function of the Retinoblastoma Protein Uncovers Cyclin-Dependent Kinase 4 as a Therapeutic Target for Diet-Induced Obesity,” “Regeneration of Retinal Neurons from Müller Glia in Adult Mice,” and “Reprogramming T Cells to Interrogate Intracellular Disease Signatures.”

中文翻译：

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对最近与抗击老龄化相关的一些论文的评论：2020 年 10 月

本期综述的论文包括“通过 CRISPR-Cas9设计高效和安全的原位基因组调控以实现基因治疗”、“研究人体细胞中 LINE-1 逆转录转座的机制”、“预测肾移植存活率的机器学习方法”， ” “视网膜母细胞瘤蛋白的新型肥胖抑制功能揭示了细胞周期蛋白依赖性激酶 4 作为饮食诱导肥胖的治疗靶点”、“成年小鼠 Müller 胶质细胞视网膜神经元的再生”和“重新编程 T 细胞以询问细胞内疾病特征。”