Age-related macular degeneration (AMD) is a blinding eye disease which incidence gradually increases with age. Inflammation participates in AMD pathogenesis, including choroidal neovascularization and geographic atrophy. It is also a kind of self-protective regulation from injury for the eyes. In this review, we described inflammation in AMD pathogenesis, summarized the roles played by inflammation-related cytokines, including pro-inflammatory and anti-inflammatory cytokines, as well as leukocytes (macrophages, dendritic cells, neutrophils, T lymphocytes and B lymphocytes) in the innate or adaptive immunity in AMD. Possible clinical applications such as potential diagnostic biomarkers and anti-inflammatory therapies were also discussed. This review overviews the inflammation as a target of novel effective therapies in treating AMD.

中文翻译：

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炎症在年龄相关性黄斑变性中的作用

年龄相关性黄斑变性（AMD）是一种致盲性眼病，发病率随着年龄的增长而逐渐增加。炎症参与 AMD 发病机制，包括脉络膜新生血管和地理萎缩。它也是一种对眼睛伤害的自我保护调节。在这篇综述中，我们描述了炎症在 AMD 发病机制中的作用，总结了炎症相关细胞因子（包括促炎和抗炎细胞因子）以及白细胞（巨噬细胞、树突细胞、中性粒细胞、T 淋巴细胞和 B 淋巴细胞）在 AMD 发病机制中的作用。 AMD 的先天性或适应性免疫。还讨论了可能的临床应用，例如潜在的诊断生物标志物和抗炎疗法。本综述概述了炎症作为治疗 AMD 的新型有效疗法的目标。