Adiponectin is an adipocyte-derived circulating factor that protects various organs and tissues. Such a pleiotropic action mechanism has not yet been fully explained. Clinically important multimer adiponectin existing in serum bound to cells expressing T-cadherin, a glycosylphosphatidylinositol-anchored cadherin, but not to the cells expressing other known receptors, AdipoRs or calreticulin. Adiponectin bound to the cell-surface, accumulated inside of multivesicular bodies through T-cadherin, and increased exosome biogenesis and secretion from the cells. Such increased exosome production accompanied the reduction of cellular ceramides in endothelial cells and mouse aorta, and enhanced skeletal muscle regeneration. Significantly lower plasma exosome levels were found in mice genetically deficient in either adiponectin or T-cadherin.

中文翻译：

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JB特别评论-脂联素（一种从脂肪细胞分泌的循环因子）刺激外泌体生物发生。

脂联素是源自脂肪细胞的循环因子，可保护各种器官和组织。这种多效作用机制尚未得到充分解释。存在于血清中的临床上重要的多聚体脂联素与表达T-钙粘蛋白（糖基磷脂酰肌醇锚定的钙粘蛋白）的细胞结合，但与表达其他已知受体，AdipoRs或钙网蛋白的细胞结合。脂连蛋白结合到细胞表面，通过T-钙粘着蛋白积聚在多囊泡体内，并增加了外泌体的生物发生和细胞分泌。这种增加的外泌体产生伴随着内皮细胞和小鼠主动脉中细胞神经酰胺的减少，以及骨骼肌再生的增强。在遗传缺乏脂联素或T-钙粘蛋白的小鼠中发现血浆外泌体水平明显降低。