Abstract

Aim

The purpose was to measure the effect of Oseltamivir on oxidative biomarkers and dopaminergic and serotonergic systems in brain of rats with induced hypotriglyceridemia by Bezafibrate.

Male young Wistar rats were treated as follows: group 1, NaCl 0.9%, (Controls); group 2, Oseltamivir (100 mg/kg); group 3, single dose of Bezafibrate (150 mg/kg); group 4, four dose of Bezafibrate; group 5, single dose of Bezafibrate + Oseltamivir and group 6, four doses of Bezafibrate + Oseltamivir. Drugs were given orally. Triglycerides, Dopamine, 5-hydroxyindoleacetic acid (5-HIAA), Glutathione (GSH), Hydrogen peroxide (H₂O₂₎, lipid peroxidation, as well as total ATPase activity were measured using validated methods.

Results

Oseltamivir treated animals showed lower GSH and lipid peroxidation levels and an increment in 5-HIAA in the three evaluated brain regions. Treatment with Oseltamivir also reduces H₂O₂ in the cortex and cerebellum/medulla oblongata. ATPase enzyme increased in these regions in the groups that were administered with Bezafibrate in repeated doses and in combination with Oseltamivir in single dose. Dopamine concentrations decreased in groups treated with Oseltamivir in the three evaluated regions. Also, there was a decrease in dopamine concentrations in the cerebellum/medulla oblongata of the animals treated with the combination of Oseltamivir and Bezafibrate.

Innovation and conclusion: Animals with bezafibrate induced hypo-triglyceridemia that received Oseltamivir, either in single or repeated doses, have a higher improvement of their antioxidant activity and also experienced changes in the dopaminergic and serotonergic system in their brain, intending establish the beneficial of joint administration of both drugs in obese patients.

中文翻译：

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奥司他韦对苯扎贝特治疗的大鼠脑中的氧化损伤有良好的反应

摘要

目标

目的是测量奥司他韦对苯扎贝特诱导的低甘油三酯血症大鼠脑中的氧化生物标志物以及多巴胺能和血清素能系统的影响。

雄性年轻 Wistar 大鼠如下处理：第 1 组，NaCl 0.9%，（对照）；第 2 组，奥司他韦 (100 mg/kg)；第 3 组，单剂量苯扎贝特 (150 mg/kg)；第4组，四剂苯扎贝特；第 5 组，单剂苯扎贝特 + 奥司他韦和第 6 组，四剂苯扎贝特 + 奥司他韦。药物是口服的。使用经过验证的方法测量甘油三酯、多巴胺、5-羟基吲哚乙酸 (5-HIAA)、谷胱甘肽 (GSH)、过氧化氢 (H ₂ O ₂₎、脂质过氧化以及总 ATP 酶活性。

结果

奥司他韦治疗的动物在三个评估的大脑区域显示出较低的 GSH 和脂质过氧化水平以及 5-HIAA 的增加。使用奥司他韦治疗还可以减少皮质和小脑/延髓中的H ₂ O _{2 。}在重复给药苯扎贝特和与单剂量奥司他韦联合给药的组中，这些区域的 ATP 酶升高。在三个评估区域中，奥司他韦治疗组的多巴胺浓度下降。此外，用奥司他韦和苯扎贝特联合治疗的动物的小脑/延髓中的多巴胺浓度降低。

创新与结论：苯扎贝特诱发的低甘油三酯血症动物单次或多次服用奥司他韦后，其抗氧化活性得到了更高的提高，并且大脑中的多巴胺能和血清素能系统也发生了变化，旨在建立关节的益处肥胖患者同时服用这两种药物。