Abstract

We experimentally investigate the foamability of PVP 2.5k/ethanol and amorphous α-maltose/methanol solution under moderate vacuum. We investigate the influence of the solution concentration and the impact of the container shape on the foamability. We show that spontaneous foaming is strongly influenced by the container’s shape. The concentration of the solution is another important parameter, and our results suggest that, for a given solution, there seems to be only a narrow concentration window that enables the formation of a stable foam. When loaded with a model hydrophobic drug (ibuprofen), the spontaneous foaming enhances the dispersion of the drug molecules, by acting as an additional mixing force through extensive shear of the solution.

摘要

我们通过实验研究了 PVP 2.5k/乙醇和无定形 α-麦芽糖/甲醇溶液在中等真空下的发泡性。我们研究了溶液浓度的影响和容器形状对发泡性的影响。我们表明，自发发泡受到容器形状的强烈影响。溶液的浓度是另一个重要参数，我们的结果表明，对于给定的溶液，似乎只有一个狭窄的浓度窗口可以形成稳定的泡沫。当装载模型疏水性药物（布洛芬）时，自发发泡通过溶液的广泛剪切充当额外的混合力，从而增强了药物分子的分散。