Although there are numerous reports of parallel coiled coil proteins with pH sensitive folding, there are relatively few examples of antiparallel systems. Beginning with a mutated fragment of Bcr‐Abl, an oncoprotein implicated in human leukemia, Schneider and co‐workers use a structure‐based engineering approach to generate a new pH sensitive homodimeric anti‐parallel two‐stranded coiled coil. The protein is stable under acidic solution conditions but unfolds under basic conditions with two state behavior that is governed by a glutamic acid within its hydrophobic core. When deprotonated, the glutamate destabilizes the folded state via charge repulsion with an existing Glu in the core. Responsive antiparallel coiled coils should find use in the preparation of smart self‐assembled materials. (doi: 10.1002/pep2.24180)

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封面图片，第112卷，第5期

尽管有许多关于具有pH敏感折叠的平行卷曲螺旋蛋白质的报道，但反平行反转录的例子相对较少。系统。Schneider及其同事从Bcr-Abl的突变片段开始，Bcr-Abl是一种涉及人类白血病的癌蛋白，它使用基于结构的工程方法来生成新的pH敏感的同二聚体反平行双链卷曲螺旋。该蛋白质在酸性溶液条件下是稳定的，但在碱性条件下会以其疏水核心内的谷氨酸控制的两种状态行为展开。当去质子化时，谷氨酸通过与核心中存在的Glu的电荷排斥而使折叠状态不稳定。响应性反平行螺旋线圈应用于制备智能自组装材料。（doi：10.1002 / pep2.24180）