Structural and functional diversity calls for a new classification of ABC transporters,FEBS Letters

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Structural and functional diversity calls for a new classification of ABC transporters
FEBS Letters ( IF 3.0 ) Pub Date : 2020-10-26 , DOI: 10.1002/1873-3468.13935
Christoph Thomas ₁ , Stephen G Aller ₂ , Konstantinos Beis _{3,

4} , Elisabeth P Carpenter ₅ , Geoffrey Chang ₆ , Lei Chen _{7,

8} , Elie Dassa ₉ , Michael Dean ₁₀ , Franck Duong Van Hoa ₁₁ , Damian Ekiert ₁₂ , Robert Ford ₁₃ , Rachelle Gaudet ₁₄ , Xin Gong ₁₅ , I Barry Holland ₁₆ , Yihua Huang ₁₇ , Daniel K Kahne ₁₈ , Hiroaki Kato ₁₉ , Vassilis Koronakis ₂₀ , Christopher M Koth ₂₁ , Youngsook Lee ₂₂ , Oded Lewinson ₂₃ , Roland Lill ₂₄ , Enrico Martinoia _{25,

26} , Satoshi Murakami ₂₇ , Heather W Pinkett ₂₈ , Bert Poolman ₂₉ , Daniel Rosenbaum ₃₀ , Balazs Sarkadi ₃₁ , Lutz Schmitt ₃₂ , Erwin Schneider ₃₃ , Yigong Shi ₃₄ , Show-Ling Shyng ₃₅ , Dirk J Slotboom ₂₉ , Emad Tajkhorshid ₃₆ , D Peter Tieleman ₃₇ , Kazumitsu Ueda ₃₈ , András Váradi ₃₁ , Po-Chao Wen ₃₆ , Nieng Yan ₃₉ , Peng Zhang ₄₀ , Hongjin Zheng ₄₁ , Jochen Zimmer ₄₂ , Robert Tampé ₁

Affiliation

Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany.
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, AL, USA.
Department of Life Sciences, Imperial College London, London South Kensington, UK.
Rutherford Appleton Laboratory, Research Complex at Harwell, Didcot, UK.
Structural Genomics Consortium, University of Oxford, UK.
Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China.
Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Institut Pasteur, Paris Cedex 15, France.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Department of Cell Biology and Department of Microbiology, New York University School of Medicine, NY, USA.
Faculty of Biology, Medicine and Health, The University of Manchester, UK.
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Department of Biology, Southern University of Science and Technology, Shenzhen, China.
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Sud, Orsay, France.
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan.
Department of Pathology, University of Cambridge, UK.
Structural Biology, Genentech Inc., South San Francisco, CA, USA.
Division of Integrative Bioscience and Biotechnology, POSTECH, Pohang, Korea.
Department of Biochemistry, The Bruce and Ruth Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.
Institut für Zytobiologie, Philipps-Universität Marburg, Germany.
Department of Plant and Microbial Biology, University Zurich, Switzerland.
International Research Centre for Environmental Membrane Biology, Foshan University, Foshan, China.
Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan.
Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.
Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Institute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary.
Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Department of Biology/Microbial Physiology, Humboldt-University of Berlin, Germany.
Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, China.
Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Department of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA.
Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary, AB, Canada.
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), KUIAS, Kyoto University, Japan.
Department of Molecular Biology, Princeton University, NJ, USA.
National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.

Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution, the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that currently comprises seven different types based on structural homology in the TMDs.

中文翻译：

结构和功能多样性需要 ABC 转运蛋白的新分类

ATP 结合盒 (ABC) 转运蛋白超家族的成员可转运多种化学成分不同的底物。虽然它们在核苷酸结合域（NBD）中的同名 ATP 结合盒高度保守，但它们形成易位途径的跨膜域（TMD）表现出不同的折叠和拓扑结构，这表明在进化过程中，古代运动域与不同的跨膜结合在一起协调各种细胞过程的机械系统。近年来，越来越明显的是，不同的 TMD 折叠最适合对众多 ABC 转运蛋白进行分类。因此，我们提出了一种新的 ABC 转运蛋白分类，目前根据 TMD 的结构同源性包括七种不同的类型。

更新日期：2020-10-26

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