CD163 deficiency facilitates lipopolysaccharide‐induced inflammatory responses and endotoxin shock in mice,Clinical & Translational Immunology

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CD163 deficiency facilitates lipopolysaccharide‐induced inflammatory responses and endotoxin shock in mice
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-09-25 , DOI: 10.1002/cti2.1162
Yukio Fujiwara ₁ , Koji Ohnishi ₁ , Hasita Horlad ₁ , Yoichi Saito _{1,

2,

3} , Daisuke Shiraishi ₁ , Hiroto Takeya ₁ , Daiki Yoshii ₁ , Shinjiro Kaieda ₄ , Tomoaki Hoshino ₄ , Yoshihiro Komohara _{1,

5}

Affiliation

Septic (or endotoxin) shock is a severe systemic inflammatory disease caused by bacteraemia or endotoxaemia. Although it is known that increased serum levels of CD163 are observed in septic/endotoxin shock patients, the exact function and significance of CD163 in macrophage activation remain unclear. Therefore, in the current study, we tested whether CD163 contributes to the pathogenesis of endotoxin shock in mice.

中文翻译：

CD163缺乏促进小鼠脂多糖诱导的炎症反应和内毒素休克

感染性（或内毒素）休克是由菌血症或内毒素血症引起的严重全身性炎症性疾病。尽管已知在脓毒症/内毒素休克患者中观察到血清 CD163 水平升高，但 CD163 在巨噬细胞活化中的确切功能和意义仍不清楚。因此，在目前的研究中，我们测试了 CD163 是否有助于小鼠内毒素休克的发病机制。

更新日期：2020-09-26

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