Exosomal vimentin from adipocyte progenitors accelerates wound healing,Cytoskeleton

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Exosomal vimentin from adipocyte progenitors accelerates wound healing
Cytoskeleton ( IF 2.4 ) Pub Date : 2020-09-26 , DOI: 10.1002/cm.21634
Sepideh Parvanian _{1,

2} , Fuxia Yan ₁ , Dandan Su ₁ , Leila S Coelho-Rato ₂ , Arun P Venu ₂ , Peiru Yang ₂ , Xiaoheng Zou ₁ , Yaming Jiu _{3,

4} , Hongbo Chen ₁ , John E Eriksson ₂ , Fang Cheng _{1,

2}

Affiliation

Adipose stem cell‐derived exosomes have great potential in accelerating cutaneous wound healing by optimizing fibroblast activities. Recent studies have demonstrated that exosomes play an active role in the transport of functional cytoskeletal proteins such as vimentin. Previously we showed that vimentin serves as a coordinator of the healing process. Therefore, we hypothesized that vimentin incorporated into the exosomes may contribute to mediate fibroblast activities in wound healing. Our results revealed that exosomal vimentin from adipocyte progenitor cells acts as a promoter of fibroblast proliferation, migration, and ECM secretion. Furthermore, our in vitro and in vivo experiments provide evidence that exosomal vimentin shortens the healing time and reduces scar formation. These findings suggest the reciprocal roles of exosomes and vimentin in accelerating wound healing. Exosomes can serve as an efficient transportation system to deliver and internalize vimentin into target cells, while vimentin could have an impact on exosome transportation, internalization, and cell communication.

中文翻译：

来自脂肪细胞祖细胞的外泌体波形蛋白加速伤口愈合

脂肪干细胞衍生的外泌体通过优化成纤维细胞活性，在加速皮肤伤口愈合方面具有巨大潜力。最近的研究表明，外泌体在功能性细胞骨架蛋白（如波形蛋白）的转运中发挥着积极作用。之前我们展示了波形蛋白作为愈合过程的协调者。因此，我们假设掺入外泌体的波形蛋白可能有助于介导伤口愈合中的成纤维细胞活性。我们的研究结果表明，来自脂肪细胞祖细胞的外泌体波形蛋白充当成纤维细胞增殖、迁移和 ECM 分泌的促进剂。此外，我们的体外和体内实验提供的证据表明外泌体波形蛋白缩短了愈合时间并减少了疤痕形成。这些发现表明外泌体和波形蛋白在加速伤口愈合中的相互作用。外泌体可以作为一种有效的运输系统，将波形蛋白递送并内化到靶细胞中，而波形蛋白可能对外泌体的运输、内化和细胞通讯产生影响。

更新日期：2020-11-27

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