Background

Chronic inflammation has been associated with sarcopenia and its components skeletal muscle strength and muscle mass. The aim of this systematic review and meta-analysis was to determine the relationship between systemic inflammation, muscle strength and/or muscle mass in adults.

Methods

An electronic search using keywords such as ‘acute phase proteins, cytokines and sarcopenia, muscle mass, muscle strength’ was conducted via Pubmed, Web of Science and Embase from inception until the 30th of June 2020. A meta-analysis using correlation data was performed to determine the overall relationship between inflammation and muscle strength and muscle mass in adults.

Results

Overall, 168 articles; 149 cross-sectional articles (n = 76,899 participants, 47.0 % male) and 19 longitudinal articles (n = 12,295 participants, 31.9 % male) met inclusion criteria. Independent of disease state, higher levels of C reactive protein (CRP), Interleukin (IL)-6 and Tumor necrosis factor (TNF)α were associated with lower handgrip and knee extension strength (CRP; r = −0.10, p < 0.001, IL-6; r = −0.13, p < 0.001, TNFα; r = −0.08, p < 0.001 and CRP; r = −0.18, p < 0.001, IL-6; r = −0.11, p < 0.001, TNFα; r = −0.13, p < 0.001 respectively) and muscle mass (CRP; r = −0.12, p < 0.001, IL-6; r = −0.09, p < 0.001, TNFα; r = −0.15, p < 0.001). Furthermore, higher levels of systemic inflammatory markers appeared to be associated with lower muscle strength and muscle mass over time.

Conclusion

Higher levels of circulating inflammatory markers are significantly associated with lower skeletal muscle strength and muscle mass.

中文翻译：

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炎症标志物及其与肌肉力量和质量的关联：系统评价和荟萃分析

背景

慢性炎症与肌肉减少症及其成分骨骼肌力量和肌肉质量有关。这项系统评价和荟萃分析的目的是确定成人全身炎症、肌肉力量和/或肌肉质量之间的关系。

方法

从开始到 2020 年 6 月 30 日，通过 Pubmed、Web of Science 和 Embase 使用诸如“急性期蛋白、细胞因子和肌肉减少症、肌肉质量、肌肉力量”等关键字进行了电子搜索。使用相关数据进行了荟萃分析确定成人炎症与肌肉力量和肌肉质量之间的整体关系。

结果

总共168篇文章；149 篇横断面文章（n = 76,899 名参与者，47.0% 男性）和 19 篇纵向文章（n = 12,295 名参与者，31.9% 男性）符合纳入标准。与疾病状态无关，较高水平的 C 反应蛋白 (CRP)、白细胞介素 (IL)-6 和肿瘤坏死因子 (TNF)α 与较低的握力和膝关节伸展强度 (CRP; r = -0.10, p < 0.001, IL-6；r = -0.13，p < 0.001，TNFα；r = -0.08，p < 0.001 和 CRP；r = -0.18，p < 0.001，IL-6；r = -0.11，p < 0.001，TNFα；r = -0.13，p < 0.001）和肌肉质量（CRP；r = -0.12，p < 0.001，IL-6；r = -0.09，p < 0.001，TNFα；r = -0.15，p < 0.001）。此外，随着时间的推移，较高水平的全身炎症标志物似乎与较低的肌肉力量和肌肉质量有关。

结论

较高水平的循环炎症标志物与较低的骨骼肌力量和肌肉质量显着相关。