Marine environment with vast diversity is a great natural source of many important bioactive compounds of medicinal value. In the present study, five marine sponges i.e. Hyrtios erectus, Pseudoceratina purpurea, Carteriospongia foliascens, Stylissa carteri and Axinella acanthelloides were collected from eastern coast of Andaman sea around South Andaman group of islands and their zoo-chemical profiles were analyzed. The in-vitro cytotoxic potential of the five sponge species against breast carcinoma cell line was evaluated. Alkaloid was the major zoo-chemical constituent of the sponges. Among the five sponge species studied, Hyrtios showed most promising cytotoxic effect against breast carcinoma cell line. Hexane extract of sponge inhibited the proliferation of the MCF-7 cell line. IC₅₀ value was 25 µg per ml. The IC₅₀ values of all the solvent extracts of all the four sponges were higher than 100 µg per ml. In conclusion, the sponge Hyrtios has huge pharmaceutical potential in the treatment of breast cancer.

中文翻译：

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从安达曼和尼科巴群岛采集的五种海洋海绵物种的动物化学成分分析和细胞毒性筛选

种类繁多的海洋环境是许多重要的具有医学价值的生物活性化合物的重要天然来源。在本研究中，五个海绵即Hyrtios直立人，Pseudoceratina菊，Carteriospongia foliascens，Stylissa carteri和Axinella acanthelloides从各地南安达曼群岛和他们的动物园，化学特性的安达曼海的东海岸收集进行分析。评价了这五个海绵物种对乳腺癌细胞系的体外细胞毒性潜力。生物碱是海绵的主要动物化学成分。在研究的五个海绵物种中，Hyrtios对乳腺癌细胞系显示出最有希望的细胞毒性作用。海绵的己烷提取物抑制MCF-7细胞系的增殖。IC ₅₀值为25 µg / ml。所有四个海绵的所有溶剂提取物的IC ₅₀值均高于每毫升100 µg。总之，Hyrtios海绵在治疗乳腺癌方面具有巨大的制药潜力。