Ultrasound contrast agents (UCA) have been widely used in ultrasonic medical applications. The dynamics of UCA should be simulated accurately to maximize the application effects. The acoustic radiation of UCA oscillations is affected by the liquid compressibility which has to be considered. This paper deduces a simple equation based on Keller-Miksis equation to describe the dynamics of UCA with a polymer shell, taking consideration of compressibility of the liquid. The volume of UCA shell is constant. The shell is described by the Kelvin-Voigt viscoelasticity model.The extended compressible model is verified by comparing with experimental data and Hoff model in predicting the variations of bubble radius with time, resonance frequency, damping constants and acoustical scattering cross section of the UCA microbubbles. The physical explanations of the differences between the extended compressible model and Hoff model in predicting resonance frequency and acoustical scattering cross...

中文翻译：

---

液体可压缩性对超声造影剂微泡动力学的影响

超声造影剂（UCA）已广泛用于超声医疗应用中。应精确模拟UCA的动力学，以最大程度地发挥应用效果。UCA振荡的声辐射受到必须考虑的液体可压缩性的影响。本文基于Keller-Miksis方程推导了一个简单的方程，该方程考虑了液体的可压缩性，描述了具有聚合物壳的UCA的动力学。UCA外壳的体积是恒定的。通过Kelvin-Voigt粘弹性模型描述壳层，并通过与实验数据和Hoff模型进行比较来验证扩展的可压缩模型，以预测UCA微气泡的气泡半径随时间，共振频率，阻尼常数和声散射截面的变化。 。