Background Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tumor patients at the molecular and multi-omics levels remain unclear. Methods Our study performed a comprehensive and multidimensional analysis in fourteen tumor types of The Cancer Genome Atlas (TCGA) and found body mass index (BMI)-related genes in multiple tumor types. Furthermore, we compared composite expression between normal, overweight, and obese patients of each immune cell subpopulation and metabolism gene subset. Statistical significance was calculated via the Kruskal-Wallis rank-sum test. Results Our analysis revealed that BMI-related genes are enriched in multiple tumor-related biological pathways involved in intracellular signaling, immune response, and metabolism. We also found the different relationships between BMI and different immune cell infiltration and metabolic pathway activity. Importantly, we found that many clinically actionable genes were BMI-affect genes. Conclusion Overall, our data indicated that BMI-associated molecular characteristics involved in tumor immune and metabolic pathways, which may highlight the clinical importance of considering BMI-associated molecular signatures in cancer precision medicine.

中文翻译：

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涉及肿瘤免疫和代谢途径的体重指数相关分子特征

背景 超重或肥胖已被证明是涉及多种恶性肿瘤的发病率、死亡率和治疗反应的重要风险因素。然而，健康和肥胖肿瘤患者在分子和多组学水平上的差异仍不清楚。方法 我们的研究对癌症基因组图谱 (TCGA) 的 14 种肿瘤类型进行了全面的多维分析，并在多种肿瘤类型中发现了体重指数 (BMI) 相关基因。此外，我们比较了每个免疫细胞亚群和代谢基因亚群的正常、超重和肥胖患者之间的复合表达。通过 Kruskal-Wallis 秩和检验计算统计显着性。结果 我们的分析表明，BMI 相关基因富含多种肿瘤相关的生物通路，这些通路涉及细胞内信号传导、免疫反应和代谢。我们还发现了BMI与不同免疫细胞浸润和代谢途径活性之间的不同关系。重要的是，我们发现许多临床上可操作的基因是 BMI 影响基因。结论 总体而言，我们的数据表明 BMI 相关分子特征涉及肿瘤免疫和代谢途径，这可能突出了在癌症精准医学中考虑 BMI 相关分子特征的临床重要性。我们发现许多临床上可操作的基因是 BMI 影响基因。结论 总体而言，我们的数据表明 BMI 相关分子特征涉及肿瘤免疫和代谢途径，这可能突出了在癌症精准医学中考虑 BMI 相关分子特征的临床重要性。我们发现许多临床上可操作的基因是 BMI 影响基因。结论 总体而言，我们的数据表明 BMI 相关分子特征涉及肿瘤免疫和代谢途径，这可能突出了在癌症精准医学中考虑 BMI 相关分子特征的临床重要性。