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The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice
Applied Biological Chemistry ( IF 2.3 ) Pub Date : 2020-09-25 , DOI: 10.1186/s13765-020-00541-x
Ya Wu , Fang Tan , Tianyu Zhang , Binglin Xie , Lixian Ran , Xin Zhao

Lotus leaves (Nelumbo nucifera) are widely used in medicines and foods. The investigate systematically studied the anti-obesity effect of lotus leaf extracts. It could reduce body weight, alleviate liver damage, and inhibit fat accumulation in high-fat-diet-induced obese mice. Lotus leaf extracts reduced serum alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (AKP) levels; decreased total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels in the serum; and increased high-density lipoprotein cholesterol (HDL-C) levels to improve dyslipidemia. Lotus leaves also inhibited inflammation accompanied by obesity via decreasing inflammatory cytokine interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), interferon gamma (IFN-γ), and IL-6 levels and increasing anti-inflammatory cytokine IL-4 and IL-10 levels. qPCR analysis revealed that lotus leaves upregulated peroxisome proliferator-activated receptor alpha (PPAR-α), lipoprotein lipase (LPL), carnitine palmitoyltransferase 1 (CPT1), and cholesterol 7 alpha hydroxylase (CYP7A1) mRNA expressions and downregulated peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding protein alpha (C/EBP-α) mRNA expressions, to reduce adipocyte differentiation and fat accumulation, promote oxidation of fat and decomposition of triglyceride and cholesterol. So, lotus leaves effectively regulated lipid metabolism, alleviated inflammation and liver injury in obese mice; thus, lotus leaves could be further developed as a food to combat obesity.

中文翻译:

荷叶通过调节C57BL / 6J小鼠脂质代谢对高脂饮食诱导的肥胖症的抗肥胖作用

荷叶(Nelumbo nucifera)被广泛用于药物和食品。本研究系统地研究了荷叶提取物的抗肥胖作用。它可以减轻高脂饮食诱导的肥胖小鼠的体重,减轻肝脏损害,并抑制脂肪堆积。荷叶提取物可降低血清丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST)和碱性磷酸酶(AKP)的水平;降低血清中总胆固醇(TC),甘油三酸酯(TG)和低密度脂蛋白胆固醇(LDL-C)的水平;以及增加高密度脂蛋白胆固醇(HDL-C)水平以改善血脂异常。荷叶还通过降低炎症细胞因子白介素(IL)-1β,肿瘤坏死因子-α(TNF-α),干扰素-γ(IFN-γ)抑制肥胖引起的炎症 和IL-6水平以及增加的抗炎细胞因子IL-4和IL-10水平。qPCR分析显示,荷叶上调了过氧化物酶体增殖物激活受体α(PPAR-α),脂蛋白脂酶(LPL),肉碱棕榈酰转移酶1(CPT1)和胆固醇7α羟化酶(CYP7A1)mRNA表达,并下调了过氧化物酶体增殖物激活受体γ (PPAR-γ)和CCAAT /增强子结合蛋白α(C /EBP-α)mRNA表达,以减少脂肪细胞分化和脂肪积累,促进脂肪氧化以及甘油三酸酯和胆固醇的分解。因此,荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤。因此,荷叶可以进一步发展为对抗肥胖的食物。qPCR分析显示,荷叶上调了过氧化物酶体增殖物激活受体α(PPAR-α),脂蛋白脂酶(LPL),肉碱棕榈酰转移酶1(CPT1)和胆固醇7α羟化酶(CYP7A1)mRNA表达,并下调了过氧化物酶体增殖物激活受体γ (PPAR-γ)和CCAAT /增强子结合蛋白α(C /EBP-α)mRNA表达,以减少脂肪细胞分化和脂肪积累,促进脂肪氧化以及甘油三酸酯和胆固醇的分解。因此,荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤。因此,荷叶可以进一步发展为对抗肥胖的食物。qPCR分析显示,荷叶上调了过氧化物酶体增殖物激活受体α(PPAR-α),脂蛋白脂酶(LPL),肉碱棕榈酰转移酶1(CPT1)和胆固醇7α羟化酶(CYP7A1)mRNA表达,并下调了过氧化物酶体增殖物激活受体γ (PPAR-γ)和CCAAT /增强子结合蛋白α(C /EBP-α)mRNA表达,以减少脂肪细胞分化和脂肪积累,促进脂肪氧化以及甘油三酸酯和胆固醇的分解。因此,荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤。因此,荷叶可以进一步发展为对抗肥胖的食物。和胆固醇7α羟化酶(CYP7A1)mRNA表达以及过氧化物酶体增殖物激活受体γ(PPAR-γ)和CCAAT /增强子结合蛋白α(C /EBP-α)mRNA表达下调,以减少脂肪细胞分化和脂肪积累,促进脂肪氧化,甘油三酸酯和胆固醇分解。因此,荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤。因此,荷叶可以进一步发展为对抗肥胖的食物。和胆固醇7α羟化酶(CYP7A1)mRNA表达以及过氧化物酶体增殖物激活受体γ(PPAR-γ)和CCAAT /增强子结合蛋白α(C /EBP-α)mRNA表达下调,以减少脂肪细胞分化和脂肪积累,促进脂肪氧化,甘油三酸酯和胆固醇分解。因此,荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤。因此,荷叶可以进一步发展为对抗肥胖的食物。荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤;因此,荷叶可以进一步发展为对抗肥胖的食物。荷叶可有效调节肥胖小鼠的脂质代谢,减轻炎症和肝损伤;因此,荷叶可以进一步发展为对抗肥胖的食物。
更新日期:2020-09-25
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